Precisely Maximize Dose, Minimize Side Effects, Maximize Patient Comfort

We designed the CyberKnife® System to give clinicians full confidence in their ability to treat cancer and help their patients live long, healthy and high-quality lives. It is the first and only robotic radiosurgery system to offer highly precise and customizable, non-surgical treatment options for a broad range of tumors anywhere in the body including the prostate, lung, brain, spine, liver, pancreas and kidney.

Robotic precision provides expected benefits, exceptionally well – short treatment times, sub-millimeter accuracy and improved patient outcomes. It also enables treatment of large and multiple site tumors. The unmatched accuracy and tissue-sparing abilities of the CyberKnife System enable treatment of a wide range of cancers aggressively – and with confidence.

CyberKnife Benefits

Anatomy-specific tracking and treatment delivery solutions for brain, spine, lung and prostate
CyberKnife M6 System Brochure

Treatment Delivery

The robotic precision of the CyberKnife® System enables non-invasive treatment for a wide range of cancerous and non-cancerous tumors. Sub-millimeter accuracy and precision enables effective and safe treatment virtually anywhere in the body.

The robotic precision and unique mobility of the CyberKnife System enables it to follow targets, account for movement of tumors or healthy tissue and intelligently deliver treatment with sub-millimeter precision. A robotic manipulator and a compact, lightweight linear accelerator deliver beams from thousands of non-coplanar, isocentric or non-isocentric angles. This unique approach results in excellent tumor coverage, steep dose gradients and tight dose conformity, regardless of target shape. The system-tracking capabilities eliminate the need for gating and restrictive head frames, providing greater patient comfort.

The CyberKnife System can, in some cases, be used as an alternative to surgery. It can also be used in place of conventional radiation therapy.

Radiosurgery (SRS/SBRT)

The CyberKnife System is designed for stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT). Its precise tumor tracking abilities enable delivery of high doses of radiation in only a few fractions. The CyberKnife System is the only system with the proven ability to delivery SRS and SBRT while tracking and automatically correcting for motion. You can be confident the CyberKnife System maximizes dose to the tumor while minimizing healthy tissue exposure, thereby minimizing side effects and maximizing patient comfort.

Motion Management

Target motion presents a critical challenge. The CyberKnife System is specifically engineered to adapt to even the most difficult circumstances. Intelligent treatment delivery software provides an intuitive user interface to control all interactions between the robotic manipulator, treatment couch and imaging system. The software quickly and automatically processes live images acquired throughout treatment at user-defined intervals. It also calculates offsets based on digitally reconstructed radiographs (DRRs) and sends offset data to the robotic manipulator for precise motion compensation.

The system uses different targeting and tracking methods specific to the type of tumor being treated:
  • 6D Skull Tracking System. Renders invasive stereotactic head frames obsolete by using the bony anatomy of the skull to continuously track intracranial targets and automatically correct for even the slightest shifts during treatment delivery
  • Synchrony® Respiratory Motion Tracking System. Synchronizes beam delivery with the motion of the target resulting from respiration, eliminating the need for restrictive immobilization, abdominal compression, gating, or breath-holding techniques
  • Xsight® Spine Tracking System and Xsight Spine Prone Tracking System. Use the bony anatomy of the spine to automatically locate and track tumors, eliminating the need for surgical implantation of fiducials and making radiosurgery in and near the spine more precise and less invasive. Spine treatments can be extended to patients in prone and supine positions
  • Xsight® Lung Tracking System and 1-View Tracking System. These systems work together with the Synchrony® Respiratory Motion Tracking System to eliminate the need to implant fiducials by directly and non-invasively tracking lung tumors
  • InTempo™ Adaptive Imaging System. Uses time-based image guidance to assist with tracking and correcting non-predictable intrafraction target motion
  • Lung Optimized Treatment. An integrated suite of tools that provides a complete fiducial-free clinical solution for lung cancer patients and optimizes non-invasive lung SBRT treatments with several key features
    • Simulation Application. A workflow-based application that automatically recommends the optimal choice for fiducial-free treatment of lung tumors based on specifics of clinical conditions
    • 1-View. A tracking method that works in conjunction with Synchrony Respiratory Tracking System. It tracks lung tumor motion in one of two X-ray projections, enabling accurate dose delivery with radiosurgical margins in the tracked direction
    • 0-View. A treatment method applied when a lung tumor is not clearly visible in either X-ray projection. It uses ITV expansion in two X-ray projections and Xsight Spine Tracking System to track patient position

    Data Management

    Exceptional care and optimized practice outcomes begin with access to complete and up-to-date patient information. Our data management solutions consolidate patient information and make it accessible, relevant and useful to authorized users. In addition to accessibility for authorized users, our proven solution provides strong protection for patient data. The CyberKnife® Data Management System provides comprehensive storage and processing of patient data generated over the life of the planning and treatment workflow process. Our tools enable clinicians to make timely and informed medical decisions and eliminate the need for paper charting, manual data re-entry and costly third-party add-ons.

    Key capabilities:

    • Import and store imaging studies
    • Store completed treatment plans and make them available for review and approval
    • Store a record of each day’s treatment procedures
    • Manage the flow of patient data throughout the system from a single location
    • Control access to patient data through user-privilege settings in compliance with HIPAA and departmental privacy policies
    • Ensure the security of patient data with scheduled database backups and the use of multiple disk drives
    The CyberKnife Data Management System also incorporates a radiosurgery DICOM interface, which utilizes industry-standard protocols to export patient treatment plans and delivery information to an Oncology Information System. This interface enables users to send the CyberKnife treatment plan – including physician prescriptions and detailed fractions and paths – using the DICOM RT Plan Export function. Then, the CyberKnife treatment delivery record – which is comprised of the total monitor units delivered during treatment, and detailed information about the delivered fractions and paths – is sent using the DICOM RT Beams Treatment Record Export function. A Clinical Efficiency Solution is also available to improve departmental workflow efficiencies and enhance long-term data storage.

    Key features of this solution include:

    • TxView. A Web-based solution for viewing and approving patient set-up positioning before and during treatment so physicians no longer must look over the therapist shoulders to assess treatment progress
    • Report Administration. A powerful tool that enables users to generate various patient, QA, departmental reports for analysis and record keeping — easily accessible from the MultiPlan® dashboard with the ability to digitally sign or initial a wide range of documents
    • Storage Vault. 10TB of storage space for up to 5,000 patients that integrates seamlessly into the CyberKnife System network

    Treatment Planning

    Our treatment planning tools align with the realities of today’s practice and the way people work. An effective plan requires input from physicists, radiation oncologists, surgeons and others involved in the workflow. Our MultiPlan ® System simplifies the requirements for everyone contributing to a plan and provides a comprehensive set of tools that make each plan a success. Providing the most comprehensive set of tools available for precise treatment planning, the MultiPlan ® System enables generation of high-quality treatment plans for the CyberKnife ® System.

    Key features include:

    • QuickPlan®. Automates the planning process, including the parameter settings and dose calculations
    • AutoSegmentation™. Leverages CT and MRI image information to automatically generate accurate contours for intracranial and male pelvic anatomy
    • Sequential Optimization. Based on an optimization algorithm for rapidly developing truly individualized plans
    • Monte Carlo Dose Calculation. Considered a gold standard for dose calculation —produces dosing results in minutes rather than hours or even days
    • 4D Treatment Optimization and Planning System. Offers true 4D treatment planning that accounts for tumor movements as well as shifts in surrounding healthy tissue and critical structures
    • MultiPlan® MD Suite. Delivers a comprehensive set of remotely-accessible planning tools for image fusion, contouring, dose calculation and treatment plan review
    • PlanTouch™. Extends review and approval functions (via mobile device) — enhances collaboration by enabling authorized users to access and share plans



    The CyberKnife System provided a convenient and minimally invasive treatment option for this patient with recurrent ovarian carcinoma who had failed previous surgery and chemotherapy.

    The ability to track and correct for prostate movements during treatment reduced uncertainty in target location, thereby allowing smaller treatment volumes than those possible using conventional IMRT systems.

    The patient was considered to be inoperable, and was referred by the neurosurgeon for radiosurgery using the CyberKnife® Robotic Radiosurgery System.

    Patient was unwilling to undergo a second thoracotomy, and instead chose to receive CyberKnife® treatment of the lesion with concurrent chemotherapy.

    The treatment of both malignant as well as benign tumors of the spine using CyberKnife radiosurgery began in 1997. Treatment of spine lesions using single fraction radiosurgery has been a successful treatment strategy at UPMC over the past four years.


    System Options

    The CyberKnife® M6™ System has the capabilities and efficiency required for every radiation oncology practice – for the treatments utilized today and setting a foundation for those of tomorrow. It is the only truly robotic system in the market, developed to meet the evolving needs of the most demanding radiation oncology programs for dedicated SBRT.

    Benefits of the CyberKnife M6 System:

    • Unmatched clinical excellence
    • Patient focused design
    • Capabilities to treat more patients and expand practice
    With the new InCise™ Multileaf Collimator (optional on the FI version), the CyberKnife M6 System is the only clinical solution to combine the benefits of the Multileaf Collimator (MLC) beam shaping with continual image guidance and non-isocentric, non-coplanar treatment delivery. Precisely sculpting dose to spare healthy tissue while maintaining sub-millimeter accuracy – even for targets that move during respiration – the CyberKnife M6 System is the clinical solution required when accuracy, flexibility, and efficiency are essential. Created to make precise, personalized treatments an option for every patient, the CyberKnife M6 System offers a comprehensive set of clinical features. Indication-specific tumor tracking with automatic correction throughout treatment, true robotic mobility, and advanced collimation integrate seamlessly into the only system to automatically stay on target during patient and tumor motion. It enables treatment of tumors anywhere in the body with confidence and without compromise.

    Designed with the patient in mind, the CyberKnife M6 System enhances patient comfort and improves the patient experience in a number of ways:

    • Easy and efficient treatment
    • Frameless and non-invasive
    • Uniquely personalized treatments
    • Soothing environmental elements
    The CyberKnife M6 System introduces clinical capabilities not possible with other treatment systems. With the flexibility of the InCise™ Multileaf Collimator and robotic delivery, tumors previously thought untreatable with radiosurgery and SBRT can now be treated efficiently, with unrivaled accuracy and tissue sparing. Clinicians have the freedom to choose the very best treatment for each patient, expanding the field of radiosurgery with unmatched possibilities.


    The CyberKnife M6 System is available in three configurations*:

    Proven, non-invasive prostate cancer treatment
    CyberKnife Business Case Study 
    Winthrop University Hospital