{"id":34335,"date":"2024-10-15T12:26:39","date_gmt":"2024-10-15T17:26:39","guid":{"rendered":"https:\/\/www.accuray.com\/?post_type=studies&p=34335"},"modified":"2024-10-30T17:20:13","modified_gmt":"2024-10-30T22:20:13","slug":"clinical-application-of-synchrony-fiducial-tracking-in-ultra-hypofractionated-prostate-radiotherapy","status":"publish","type":"studies","link":"https:\/\/www.accuray.com\/ja\/case-studies\/clinical-application-of-synchrony-fiducial-tracking-in-ultra-hypofractionated-prostate-radiotherapy\/","title":{"rendered":"Clinical Application of Synchrony\u00ae Fiducial Tracking in Ultra-Hypofractionated Prostate Radiotherapy"},"content":{"rendered":"\t\t
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\n\t\t\t\t\t\t\t\t\t< View All Case Studies<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tCASE STUDY | SK\u00c5NE UNIVERSITY HOSPITAL, LUND, SWEDEN\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Clinical Application of Synchrony\u00ae Fiducial Tracking in Ultra-Hypofractionated Prostate Radiotherapy<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tDownload Case Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tAt our center we have introduced real-time MLC-tracking for ultra-hypofractionated\nprostate radiotherapy. This approach mitigates uncertainties arising from prostate\nmotion and utilizes an MRI-based synthetic CT workflow. Here we present a case study\ncentred on a patient with prostate cancer receiving hypofractionated treatment using\nSynchrony\u00ae Fiducial Tracking\u2122, a real-time target tracking technology using MLC and\njaw motion to correct for target motion. A synthetic CT was used as a reference for\ndose planning, fiducial recognition and image registration.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\u201cWe believe that the future of prostate radiotherapy such\nas ultra-hypofractionated radiation therapy and stereotactic\nbody radiation therapy (SBRT) requires mitigation of motion\nuncertainties and that real-time tracking is an attractive option.\u201d\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Case Challenge<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tEnsuring accurate synthetic CT matching with daily kVCT and precise\nMLC and jaw tracking for ultra-hypofractionated prostate radiotherapy.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Offset from registered position<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\tFigure 1: Offset from reference position for each fraction and axis. Axis in machine coordinate system, sup\/inf meaning superior\/inferior, where superior in the head direction and thus into the bore, ant\/post meaning anterior\/posterior positive is in the anterior direction. Offset was calculated by Synchrony\u00ae from kV images with 6 kV images per gantry rotation, and a rotation time of 24s.<\/em>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Facts at-a-glance<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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FACILITY NAME<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tSk\u00e5ne University Hospital\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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LOCATION<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tLund, Sweden\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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ABOUT<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tClinical implementation of Synchrony\u00ae\nFiducial Tracking\u2122, real-time tracking\nwith MLC and Jaw correction in ultrahypofractionated\nprostate cancer patients\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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TREATMENT SYSTEM EXPERIENCE<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tIn 2008 the TomoTherapy\u00ae System was\nintroduced. In 2021 the Centre upgraded\nto a Radixact\u00ae System and started using\nSynchrony real-time tracking in 2022\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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UPGRADE TECHNOLOGY SOLUTIONS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tSynchrony, ClearRT\u00ae kVCT imaging\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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INDICATION<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tProstate cancer\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Treatment Rationale<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tWith the goal of minimizing uncertainties from prostate motion during ultra-hypofractionated prostate radiotherapy, we employed online real-time MLC-tracking. The synthetic CT, derived from deep learning-assisted MRI sequences, served as a reference for dose planning, fiducial recognition, and image registration. This approach eliminates the need for a dose planning CT. The synthetic fiducials\u2019 position and the synthetic CT\u2019s correlation to the daily CT were crucial aspects for successful implementation. The patient was a pioneer in our forthcoming trial Real-time Motion Management During Prostate and Lung Radiotherapy (REMIND). The patient was prescribed 42.7Gy in 7 fractions with a CTV-PTV margin of 7mm.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Outcomes \/ Conclusions<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tThe synthetic CT generation method proved effective with minor deviations in dose calculations. The first patient\u2019s median and range 3D deviations from the reference position across seven fractions varied but confirmed the importance of MLC-tracking for precise corrections, see Figure 1. The daily CT matched the synthetic CT well, see Figure 2, validating the feasibility of fiducial tracking based on synthetic CT generated using deep learning. The patient tolerated the treatment well. This case demonstrates the potential of the technique in reducing uncertainties during treatment.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tImportant Safety Information Most side effects of radiotherapy, including radiotherapy delivered with Accuray systems, are mild and temporary, often involving fatigue, nausea, and skin irritation. Side effects can be severe, however, leading to pain, alterations in normal body functions\n(for example, urinary or salivary function), deterioration of quality of life, permanent injury, and even death. Side effects can occur during or shortly after radiation treatment or in the months and years following radiation. The nature and severity of side effects depend on many factors, including the size and location of the treated tumor, the treatment technique (for example, the radiation dose), and the patient\u2019s general medical condition, to name a few. For more details about the side effects of your radiation therapy, and to see if treatment with an Accuray product is right for you, ask your doctor. Accuray Incorporated as a medical device manufacturer cannot and does not recommend specific treatment approaches. Individual results may vary.\n\n

\u00a9 2023 Accuray Incorporated. All Rights Reserved. Accuray, the Accuray logo, and other trademarks are trademarks or registered trademarks of Accuray Incorporated and may not be used without permission. For more information on Accuray and its trademarks, please visit www.accuray.com\/trademarks. MKT004413<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Here we present a case study centred on a patient with prostate cancer receiving hypofractionated treatment using Synchrony\u00ae Fiducial Tracking\u2122, a real-time target tracking technology using MLC and jaw motion to correct for target motion. A synthetic CT was used as a reference for dose planning, fiducial recognition and image registration.<\/p>\n","protected":false},"featured_media":34361,"menu_order":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_links_to":"","_links_to_target":""},"categories":[1265],"studies_products":[],"case_studies_products":[1268],"class_list":["post-34335","studies","type-studies","status-publish","has-post-thumbnail","hentry","category-tomotherapy-radixact","case_studies_products-tomotherapy-radixact"],"acf":[],"yoast_head":"\nClinical Application of Synchrony\u00ae Fiducial Tracking in Ultra-Hypofractionated Prostate Radiotherapy - Accuray<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.accuray.com\/case-studies\/clinical-application-of-synchrony-fiducial-tracking-in-ultra-hypofractionated-prostate-radiotherapy\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Clinical Application of Synchrony\u00ae Fiducial Tracking in Ultra-Hypofractionated Prostate Radiotherapy\" \/>\n<meta property=\"og:description\" content=\"Here we present a case study centred on a patient with prostate cancer receiving hypofractionated treatment using Synchrony\u00ae Fiducial Tracking\u2122, a real-time target tracking technology using MLC and jaw motion to correct for target motion. 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