{"id":37225,"date":"2025-07-14T15:00:14","date_gmt":"2025-07-14T20:00:14","guid":{"rendered":"https:\/\/www.accuray.com\/?post_type=studies&p=37225"},"modified":"2025-11-03T08:48:27","modified_gmt":"2025-11-03T13:48:27","slug":"transition-to-the-radixact-system-for-pediatric-total-body-irradiation-tbi-treatment","status":"publish","type":"studies","link":"https:\/\/www.accuray.com\/ja\/case-studies\/transition-to-the-radixact-system-for-pediatric-total-body-irradiation-tbi-treatment\/","title":{"rendered":"Transition to the Radixact\u00ae System for Pediatric Total Body Irradiation (TBI) Treatment"},"content":{"rendered":"\t\t
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\n\t\t\t\t\t\t\t\t\t< View All Case Studies<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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CASE STUDY | RADIXACT\u00ae SYSTEM – TOTAL BODY IRRADIATION<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Transition to the Radixact\u00ae System for Pediatric Total Body Irradiation (TBI) Treatment<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tDownload Case Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tA 6-year-old boy presented with a high white blood cell count and a mediastinal mass.\nHe was diagnosed with high-risk T-cell acute lymphoblastic leukemia (ALL) and treated in\nthe ALLTogether1 trial1<\/sup>. During induction therapy with regimen B, the patient continued to\nhave high levels of minimal residual disease (MRD). Subsequently, the patient underwent\nconsolidation treatment, leading to a decrease in MRD levels. As a result, the patient was\nrecommended for a hematopoietic stem cell transplant (HSCT).\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Case Challenge:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tDue to the patient\u2019s high-risk disease, the HSCT was planned during his first complete remission. TBI was indicated as\npart of conditioning for stem cell transplant. This is the first patient treated since transitioning from the TomoTherapy\u00ae\nSystem to the Radixact\u00ae System. Pediatric TBI patients are treated on the Radixact System using TomoDirect\u2122 to achieve\na homogenous dose distribution and to minimize dose to the lungs.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Planning CT scan <\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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ClearRT\u00ae scan<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Facts at-a-glance<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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FACILITY NAME<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tUniversity Hospitals Birmingham\nNHS Trust\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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LOCATION<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tBirmingham, United Kingdom\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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ABOUT<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tThe first pediatric TBI case\ntreated using the Radixact\u00ae\nSystem, demonstrating workflow\nefficiencies\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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TREATMENT SYSTEM EXPERIENCE<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tRadixact X7 System\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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TECHNOLOGY SOLUTIONS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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  • VOLO\u00ae Ultra Optimizer<\/li>
  • PreciseART\u00ae Offline Adaptive
    Radiation Therapy Option<\/li>
  • ClearRT\u00ae<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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    Treatment:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    The patient was treated under general anesthesia with comprehensive immobilization using Medtech head curve Q2, Moldcare cushion, full body vac bag on lock board and foot stocks. Tattoos were placed anteriorly and laterally at the\nchest and pelvis for alignment. Helical kVCT images using ClearRT\u00ae were performed\nusing a whole-body protocol with a field of view (FOV) of 500 mm.<\/p>\n\n

    The plan was created using VOLO\u00ae Ultra Optimizer in TomoDirect\u2122 mode, with a\nfixed jaw and a 5 cm field. Ten fields were used to deliver a median dose of 12 Gy across six fractions, ensuring uniform dose distribution. The mean dose to the inner lungs was reduced to approximately\n10.5 Gy. Special attention was given to the spleen, included as an optimization target. Robustness plans were created to evaluate the effect of a 10 mm shift in all cardinal directions. Plan assessments were performed using PreciseART\u00ae Offline Adaptive Radiation Therapy option for the first two fractions.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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    Outcomes:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    • No grade >2 side effects observed during treatment<\/li>
    • Patient discharged from hospital seven weeks after
      stem cell transplant<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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      Rationale for Transitioning from Extended Source to Surface Distance (ESSD) Technique to the Radixact\u00ae System<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      TomoTherapy\u00ae System Vs. Radixact System<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      Conclusion:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      • Using the Radixact System, there was significant improvement in plan quality compared to the ESSD technique<\/li>
      • Implementing time reductions on Radixact System vs. TomoTherapy System has resulted in a more tolerable treatment experience and a decreased impact on the department workflow<\/li>
      • Assessments can be effectively performed using the PreciseART\u00ae Offline Adaptive Radiation Therapy software, ensuring the plan\u2019s robustness<\/li>
      • Treatment was tolerated well by the patient<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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        \u00a0<\/p>

        1<\/sup><\/span>https:\/\/www.cancerresearchuk.org\/about-cancer\/find-a-clinical-trial\/a-study-looking-at-treatment-children-young-adults-with-newly-diagnosed-acute-lymphoblatic-leukaemia-alltogether1<\/p>

        Important Safety Information
        Most side effects of radiotherapy, including radiotherapy delivered with Accuray systems, are mild and temporary, often involving fatigue, nausea, and skin irritation. Side effects can be severe, however, leading to pain, alterations in normal body functions
        (for example, urinary or salivary function), deterioration of quality of life, permanent injury, and even death. Side effects can occur during or shortly after radiation treatment or in the months and years following radiation. The nature and severity of side effects depend on many factors, including the size and location of the treated tumor, the treatment technique (for example, the radiation dose), and the patient\u2019s general medical condition, to name a few. For more details about the side effects of your radiation therapy, and to see if treatment with an Accuray product is right for you, ask your doctor. Accuray Incorporated as a medical device manufacturer cannot and does not recommend specific treatment approaches. Individual results may vary.<\/p>

        \u00a9 2024 Accuray Incorporated. All Rights Reserved. Accuray, the Accuray logo, and other trademarks are trademarks or registered trademarks of Accuray Incorporated and may not be used without permission. For more information on Accuray and its trademarks, please visit www.accuray.com\/trademarks. MKT004730<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

        A 6-year-old boy presented with a high white blood cell count and a mediastinal mass. He was diagnosed with high-risk T-cell acute lymphoblastic leukemia (ALL) and treated in the ALLTogether1 trial1. During induction therapy with regimen B, the patient continued to have high levels of minimal residual disease (MRD). Subsequently, the patient underwent
        \nconsolidation treatment, leading to a decrease in MRD levels. As a result, the patient was recommended for a hematopoietic stem cell transplant (HSCT).<\/p>\n","protected":false},"featured_media":37226,"menu_order":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_links_to":"","_links_to_target":""},"categories":[1265],"studies_products":[],"case_studies_products":[1268],"class_list":["post-37225","studies","type-studies","status-publish","has-post-thumbnail","hentry","category-tomotherapy-radixact","case_studies_products-tomotherapy-radixact"],"acf":[],"yoast_head":"\nPediatric Total Body Irradiation on the Radixact System - Accuray<\/title>\n<meta name=\"description\" content=\"Learn how the Radixact System was used to treat pediatric total body irradiation (TBI) treatment at University Hospitals Birmingham\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.accuray.com\/case-studies\/transition-to-the-radixact-system-for-pediatric-total-body-irradiation-tbi-treatment\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Transition to the Radixact\u00ae System for Pediatric Total Body Irradiation (TBI) Treatment\" \/>\n<meta property=\"og:description\" content=\"Learn how the Radixact System was used to treat pediatric total body irradiation (TBI) treatment at University Hospitals Birmingham\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.accuray.com\/case-studies\/transition-to-the-radixact-system-for-pediatric-total-body-irradiation-tbi-treatment\/\" \/>\n<meta property=\"og:site_name\" content=\"Accuray\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/AccurayIncorporated\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-03T13:48:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.accuray.com\/wp-content\/uploads\/Rationale_2.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1558\" \/>\n\t<meta property=\"og:image:height\" content=\"1258\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Accuray\" \/>\n<meta name=\"twitter:label1\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data1\" content=\"5\u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.accuray.com\\\/case-studies\\\/transition-to-the-radixact-system-for-pediatric-total-body-irradiation-tbi-treatment\\\/\",\"url\":\"https:\\\/\\\/www.accuray.com\\\/case-studies\\\/transition-to-the-radixact-system-for-pediatric-total-body-irradiation-tbi-treatment\\\/\",\"name\":\"Pediatric Total Body Irradiation on the Radixact System - 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