{"id":42756,"date":"2025-11-19T15:37:59","date_gmt":"2025-11-19T20:37:59","guid":{"rendered":"https:\/\/www.accuray.com\/?post_type=studies&p=42756"},"modified":"2025-11-24T16:02:21","modified_gmt":"2025-11-24T21:02:21","slug":"the-early-experience-of-synchrony-inultra-hypofractionation-for-prostatecancer-a-case-series","status":"publish","type":"studies","link":"https:\/\/www.accuray.com\/ja\/case-studies\/the-early-experience-of-synchrony-inultra-hypofractionation-for-prostatecancer-a-case-series\/","title":{"rendered":"The Early Experience of Synchrony\u00ae in Ultra- Hypofractionation for Prostate Cancer: A Case Series"},"content":{"rendered":"\t\t
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\n\t\t\t\t\t\t\t\t\t< View All Case Studies<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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CASE STUDY | CHIANG MAI UNIVERSITY, THAILAND<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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The Early Experience of Synchrony\u00ae inUltra- Hypofractionation for ProstateCancer: A Case Series<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tDownload Case Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Authors:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tPiyapasara Toapichattrakul, Pooriwat Muangwong, Anupong\nKongsa, Wannapha Nobnop, Anirut Watcharawipha, Ekkasit\nTharavichitkul (Chiang Mai University, Thailand)\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Purpose:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tThis case series investigates the early real-world performance of Synchrony\u00ae real-time motion tracking during\nultra-hypofractionated prostate radiotherapy on the Radixact\u00ae System.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Study Design:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Number of Patients<\/strong><\/span><\/td>5 men with localized prostate cancer (3 favourable inter-mediate risk, 1 unfavourable intermediate risk, 1 N\/A); 80% of patients received concurrent ADT<\/span><\/td><\/tr>
Motion Management Technique<\/strong><\/span><\/td>Synchrony real-time tracking with automatic beam pauses if thresholds exceeded. Three gold fiducials implanted transperineally under ultrasound guidance<\/span><\/td><\/tr>
Planning<\/strong><\/span><\/td>3 mm isotropic CTV-to-PTV margin; VOLO\u2122 Ultra used for dose optimization<\/span><\/td><\/tr>
Treatment<\/strong><\/span><\/td>SBRT with 36.25 Gy in 5 fractions, using criteria adapted from the PACE-B trial. Daily helical kVCT using ClearRT\u00ae for initial patient setup via fiducial marker matching<\/span><\/td>\t\t\t<\/tr>\r\n\t\t<\/tbody>\r\n\r\n\t\t\r\n\t\t\t<\/table>\r\n\t\t<\/div>\r\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Example dose distribution for ultra-hypofractionated prostate cancer treatment<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Key Findings:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Dosimetry<\/strong><\/span><\/td>All patients met target coverage; two cases slightly exceeded bladder\/rectum dose constraints<\/span><\/td><\/tr>
Treatment Efficiency<\/strong><\/span><\/td>Mean beam-on time increased by 13.9% due to motion-related pauses; average beam-on time 586.52 s<\/span><\/td><\/tr>
PSA Response<\/strong><\/span><\/td>Rapid decline, averaging \u22124.27 ng\/mL\/month<\/span><\/td><\/tr>
Planning Constraints<\/strong><\/span><\/td>All organ at risk constraints of the RTOG 0234 protocol were met.<\/span><\/td><\/tr>
Toxicity<\/strong><\/span><\/td>Median follow-up 2 months. Only one patient experienced Grade 1 GI toxicity (diarrhea), which resolved with supportive care<\/span><\/td>\t\t\t<\/tr>\r\n\t\t<\/tbody>\r\n\r\n\t\t\r\n\t\t\t<\/table>\r\n\t\t<\/div>\r\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Conclusion:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\u201cSynchrony successfully enhances ultra-hypofractionated prostate radiotherapy by providing dynamic motion management throughout treatment delivery\u2026 This operational approach supports both therapeutic effectiveness \u2014 as evidenced by rapid biochemical response \u2014 and an excellent safety profile, confirming its value in optimizing prostate\nultra-hypofractionation delivery.\u201d\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Toapichattrakul P, Muangwong P, Kongsa A, et al. (May 18, 2025) The Early Experience of Synchrony in Ultra-Hypofractionation for Prostate Cancer: A Case Series. Cureus 17(5): e84323. doi:10.7759\/cureus.84323<\/p>

Synchrony\u00ae is available in the US and EU markets. This feature may not be commercially available in all markets and is subject to regulatory clearance or approval. Kindly contact your regional Accuray representative or distributor to confirm the regulatory status.<\/p>

Important Safety Information:<\/p>

Most side effects of radiotherapy, including radiotherapy delivered with Accuray systems, are mild and temporary, often involving fatigue, nausea, and skin irritation. Side effects can be severe, however, leading to pain, alterations in normal body functions (for example, urinary or salivary function), deterioration of quality of life, permanent injury, and even death. Side effects can occur during or shortly after radiation treatment or in the months and years following radiation. The nature and severity of side effects depend on many factors, including the size and location of the treated tumor, the treatment technique (for example, the radiation dose), and the patient\u2019s general medical condition, to name a few. For more details about the side effects of your radiation therapy, and to see if treatment with an Accuray product is right for you, ask your doctor. Accuray Incorporated as a medical device manufacturer cannot and does not recommend specific treatment approaches. Individual results may vary.<\/p>

\u00a9 2025 Accuray Incorporated. All Rights Reserved. Accuray, the Accuray logo, and other trademarks are trademarks or registered trademarks of Accuray Incorporated and may not be used without permission. For more information on Accuray and its trademarks, please visit www.accuray.com\/trademarks. MKTRXCSCC17092025#7<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

This case series investigates the early real-world performance of Synchrony\u00ae real-time motion tracking during ultra-hypofractionated prostate radiotherapy on the Radixact\u00ae System.<\/p>\n","protected":false},"featured_media":42757,"menu_order":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_links_to":"","_links_to_target":""},"categories":[1866],"studies_products":[],"case_studies_products":[1861,1268],"class_list":["post-42756","studies","type-studies","status-publish","has-post-thumbnail","hentry","category-synchrony-on-radixact","case_studies_products-synchrony","case_studies_products-tomotherapy-radixact"],"acf":[],"yoast_head":"\nPediatric Total Body Irradiation on the Radixact System - Accuray<\/title>\n<meta name=\"description\" content=\"Learn how the Radixact System was used to treat pediatric total body irradiation (TBI) treatment at University Hospitals Birmingham\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.accuray.com\/case-studies\/the-early-experience-of-synchrony-inultra-hypofractionation-for-prostatecancer-a-case-series\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Early Experience of Synchrony\u00ae in Ultra- Hypofractionation for Prostate Cancer: A Case Series\" \/>\n<meta property=\"og:description\" content=\"Learn how the Radixact System was used to treat pediatric total body irradiation (TBI) treatment at University Hospitals Birmingham\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.accuray.com\/case-studies\/the-early-experience-of-synchrony-inultra-hypofractionation-for-prostatecancer-a-case-series\/\" \/>\n<meta property=\"og:site_name\" content=\"Accuray\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/AccurayIncorporated\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-24T21:02:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.accuray.com\/wp-content\/uploads\/920e88b016f511f082dee3c6928ea582-Fig-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"986\" \/>\n\t<meta property=\"og:image:height\" content=\"382\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Accuray\" \/>\n<meta name=\"twitter:label1\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data1\" content=\"3\u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.accuray.com\\\/case-studies\\\/the-early-experience-of-synchrony-inultra-hypofractionation-for-prostatecancer-a-case-series\\\/\",\"url\":\"https:\\\/\\\/www.accuray.com\\\/case-studies\\\/the-early-experience-of-synchrony-inultra-hypofractionation-for-prostatecancer-a-case-series\\\/\",\"name\":\"Pediatric Total Body Irradiation on the Radixact System - 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