{"id":42841,"date":"2025-11-19T17:06:54","date_gmt":"2025-11-19T22:06:54","guid":{"rendered":"https:\/\/www.accuray.com\/?post_type=studies&p=42841"},"modified":"2025-11-24T16:00:29","modified_gmt":"2025-11-24T21:00:29","slug":"radixact-system-with-synchrony-fiducial-trackingfor-stereotactic-body-radiotherapy-in-prostatecancer-a-single-center-experience-on-toxicity","status":"publish","type":"studies","link":"https:\/\/www.accuray.com\/ja\/case-studies\/radixact-system-with-synchrony-fiducial-trackingfor-stereotactic-body-radiotherapy-in-prostatecancer-a-single-center-experience-on-toxicity\/","title":{"rendered":"Radixact\u00ae System with Synchrony\u00ae Fiducial Tracking for Stereotactic Body Radiotherapy in Prostate Cancer: A Single-center Experience on Toxicity"},"content":{"rendered":"\t\t
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\n\t\t\t\t\t\t\t\t\t< View All Case Studies<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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CASE STUDY | RADIOTHERAPY, EMICENTER \u2014 NAPOLI, ITALY<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Radixact\u00ae System With Synchrony\u00ae Fiducial Tracking\nFor Stereotactic Body Radiotherapy in Prostate\nCancer: A Single-center Experience on Toxicity<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tDownload Case Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Authors:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tLorella Lo Conte Jr., Vincenzo Iorio, Ida Rosalia Scognamiglio,\nAntonio Russo, Ersilia Donda, Alfonsina Pepe, Anna Viggiano,\nFerdinando Francomacaro, Ivona Zlatkova, Caterina Muto\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Purpose:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tTo evaluate the safety of patients with localized prostate cancer\nundergoing SBRT using the Radixact\u00ae System with Synchrony\u00ae\nFiducial Tracking\u2122, a real-time motion tracking and correction system.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Methods:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Design<\/strong><\/span><\/td>Retrospective study of 43 prostate cancer patients<\/span><\/td><\/tr>
Risk Groups<\/strong><\/span><\/td>21% low risk, 35% favorable intermediate, 30% unfavorable intermediate, 14% high risk<\/span><\/td><\/tr>
Dose<\/strong><\/span><\/td>36.25 Gy in 5 fractions, delivered every other day<\/span><\/td><\/tr>
Planning<\/strong><\/span><\/td>The prostate was contoured as the CTV, and a 4 mm margin was added in all directions to create the PTV, except posteriorly (3 mm)<\/span><\/td><\/tr>
Motion Management<\/strong><\/span><\/td>Synchrony real-time adaptive tracking with 3 fiducial markers<\/span><\/td><\/tr>
Follow-up<\/strong><\/span><\/td>Median of 14 months (range: 0\u201332 months)<\/span><\/td>\t\t\t<\/tr>\r\n\t\t<\/tbody>\r\n\r\n\t\t\r\n\t\t\t<\/table>\r\n\t\t<\/div>\r\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Results:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tAll patients completed the planned\nultra-hypofractionated regimen\nwithout treatment interruptions.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Acute Toxicity<\/strong><\/span><\/td>
  • GU: 42% had symptoms; 5% had Grade 2<\/li>
  • GI: 28% had symptoms; 2% had Grade 2<\/li>
  • No grade \u22653 toxicities<\/li><\/ul><\/span><\/td><\/tr>
Late Toxicity (Available for 40 Patients)<\/strong><\/span><\/td>
  • GU: 23% had symptoms; 3% had Grade 2<\/li>
  • GI: 28% had symptoms; 15% had Grade 2 (mostly managed with topical therapy; one required endoscopic treatment)<\/li>
  • No grade \u22653 toxicities<\/li><\/ul><\/span><\/td>\t\t\t<\/tr>\r\n\t\t<\/tbody>\r\n\r\n\t\t\r\n\t\t\t<\/table>\r\n\t\t<\/div>\r\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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    Conclusion:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    \u201cOur initial findings suggest that prostate SBRT using Radixact TomoTherapy\u00ae with Synchrony fiducial tracking is a safe treatment approach with acceptable acute and early late toxicity rates. However, as we acknowledge, expanding the patient cohort and extending the follow-up period are crucial to definitively assess the long-term safety profile and clinical outcomes of this treatment modality for localized PC\u201d<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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    Synchrony\u00ae is available in the US and EU markets. This feature may not be commercially available in all markets and is subject to regulatory clearance or approval. Kindly contact your regional Accuray representative or distributor to confirm the regulatory status.<\/p>\n

    Important Safety Information:<\/p>\n

    Most side effects of radiotherapy, including radiotherapy delivered with Accuray systems, are mild and temporary, often involving fatigue, nausea, and skin irritation. Side effects can be severe, however, leading to pain, alterations in normal body functions (for example, urinary or salivary function), deterioration of quality of life, permanent injury, and even death. Side effects can occur during or shortly after radiation treatment or in the months and years following radiation. The nature and severity of side effects depend on many factors, including the size and location of the treated tumor, the treatment technique (for example, the radiation dose), and the patient\u2019s general medical condition, to name a few. For more details about the side effects of your radiation therapy, and to see if treatment with an Accuray product is right for you, ask your doctor. Accuray Incorporated as a medical device manufacturer cannot and does not recommend specific treatment approaches. Individual results may vary.<\/p>\n

    \u00a9 2025 Accuray Incorporated. All Rights Reserved. Accuray, the Accuray logo, and other trademarks are trademarks or registered trademarks of Accuray Incorporated and may not be used without permission. For more information on Accuray and its trademarks, please visit www.accuray.com\/trademarks. MKTRXCSCC220925#8<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

    To evaluate the safety of patients with localized prostate cancer undergoing SBRT using the Radixact\u00ae System with Synchrony\u00ae Fiducial Tracking\u2122, a real-time motion tracking and correction system.<\/p>\n","protected":false},"featured_media":42674,"menu_order":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_links_to":"","_links_to_target":""},"categories":[1866],"studies_products":[],"case_studies_products":[1861,1268],"class_list":["post-42841","studies","type-studies","status-publish","has-post-thumbnail","hentry","category-synchrony-on-radixact","case_studies_products-synchrony","case_studies_products-tomotherapy-radixact"],"acf":[],"yoast_head":"\nPediatric Total Body Irradiation on the Radixact System - Accuray<\/title>\n<meta name=\"description\" content=\"Learn how the Radixact System was used to treat pediatric total body irradiation (TBI) treatment at University Hospitals Birmingham\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.accuray.com\/case-studies\/radixact-system-with-synchrony-fiducial-trackingfor-stereotactic-body-radiotherapy-in-prostatecancer-a-single-center-experience-on-toxicity\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Radixact\u00ae System with Synchrony\u00ae Fiducial Tracking for Stereotactic Body Radiotherapy in Prostate Cancer: A Single-center Experience on Toxicity\" \/>\n<meta property=\"og:description\" content=\"Learn how the Radixact System was used to treat pediatric total body irradiation (TBI) treatment at University Hospitals Birmingham\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.accuray.com\/case-studies\/radixact-system-with-synchrony-fiducial-trackingfor-stereotactic-body-radiotherapy-in-prostatecancer-a-single-center-experience-on-toxicity\/\" \/>\n<meta property=\"og:site_name\" content=\"Accuray\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/AccurayIncorporated\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-24T21:00:29+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.accuray.com\/wp-content\/uploads\/RX-wbar-In-Circle.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1094\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Accuray\" \/>\n<meta name=\"twitter:label1\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data1\" content=\"3\u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.accuray.com\\\/case-studies\\\/radixact-system-with-synchrony-fiducial-trackingfor-stereotactic-body-radiotherapy-in-prostatecancer-a-single-center-experience-on-toxicity\\\/\",\"url\":\"https:\\\/\\\/www.accuray.com\\\/case-studies\\\/radixact-system-with-synchrony-fiducial-trackingfor-stereotactic-body-radiotherapy-in-prostatecancer-a-single-center-experience-on-toxicity\\\/\",\"name\":\"Pediatric Total Body Irradiation on the Radixact System - 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