{"id":42917,"date":"2025-11-20T13:30:37","date_gmt":"2025-11-20T18:30:37","guid":{"rendered":"https:\/\/www.accuray.com\/?post_type=studies&p=42917"},"modified":"2025-11-24T15:59:57","modified_gmt":"2025-11-24T20:59:57","slug":"real-time-adaptive-motion-managementin-prostate-stereotactic-body-radiationtherapy-sbrt-clinical-and-dosimetricanalysis-of-25-patients","status":"publish","type":"studies","link":"https:\/\/www.accuray.com\/ja\/case-studies\/real-time-adaptive-motion-managementin-prostate-stereotactic-body-radiationtherapy-sbrt-clinical-and-dosimetricanalysis-of-25-patients\/","title":{"rendered":"Real-time Adaptive Motion Management In Prostate Stereotactic Body Radiation Therapy (Sbrt): Clinical and Dosimetric Analysis of 25 Patients"},"content":{"rendered":"\t\t
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\n\t\t\t\t\t\t\t\t\t< View All Case Studies<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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CASE STUDY | MONTEFIORE MEDICAL CENTER<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Real-time Adaptive Motion Management In Prostate Stereotactic Body Radiation Therapy (Sbrt): Clinical and Dosimetric Analysis of 25 Patients<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tDownload Case Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Authors:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tGoddard LC, Cabrera J, Tang J, Garg MK, Tom\u00e9 WA\n(Montefiore Medical Center \/ Albert Einstein College of\nMedicine, NY, USA).\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Published:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tApril 13, 2025, Cureus Journal of Medical Science\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Methods:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Design<\/strong><\/span><\/td>Retrospective study of 25 patients with localized prostate cancer<\/span><\/td><\/tr>
Treatments<\/strong><\/span><\/td>SBRT - 40 Gy in 5 fractions<\/span><\/td><\/tr>
Planning<\/strong><\/span><\/td>Accuray Precision\u00ae Treatment Planning System using VOLO\u2122 Classic or VOLO Ultra optimizer, 2.5 cm dynamic jaws<\/span><\/td><\/tr>
Motion Management<\/strong><\/span><\/td>Synchrony\u00ae real-time motion management system on the Radixact\u00ae System<\/span><\/td><\/tr>
Follow-up<\/strong><\/span><\/td>Median 28 months; toxicity graded by CTCAE v4.03<\/span><\/td>\t\t\t<\/tr>\r\n\t\t<\/tbody>\r\n\r\n\t\t\r\n\t\t\t<\/table>\r\n\t\t<\/div>\r\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Figure 1: Measured Target Offsets for Patient 2, Fraction 4<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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(adapted from table 4 from the original article)<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Results:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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  • Dosimetry: <\/b>All plans met target coverage and organ at-risk (OAR) constraints; average PTV conformality index 1.13, homogeneity index 1.09.<\/li>\n
  • Motion: <\/b>All but one patient had \u22651 fraction with >2 mm motion; abrupt large motions (>5 mm) occurred 77 times over 36 treatments, sometimes requiring mid-treatment CT\/repositioning.<\/li>\n
  • PSA Response: <\/b>Median post-treatment PSA 0.30 ng\/mL; all patients <2.0 ng\/mL at 15 months; transient PSA \u201cbounces\u201d seen in 3 patients.<\/li>\n
  • Toxicity: <\/b>14 patients had new grade 1 genitourinary (GU) symptoms; 3 had grade 2 GU toxicity; 5 had grade 1 gastrointestinal symptoms; 3 reported grade 1 gastrointestinal symptoms; 3 reported grade 1 fatigue<\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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    Conclusion:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    \n\t\t\t\t\t\t\t\t\t\u201cOur findings suggest that prostate SBRT with Radixact Synchrony provides excellent target coverage while effectively managing intrafraction motion. The observed PSA response and OAR dose metrics support its use as a treatment modality for localized prostate cancer.\u201d\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    Limitations include the retrospective design, the small sample size, and lack of patient-reported data.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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    Synchrony\u00ae is available in the US and EU markets. This feature may not be commercially available in all markets and is subject to regulatory clearance or approval. Kindly contact your regional Accuray representative or distributor to confirm the regulatory status.<\/p>\n

    Important Safety Information:<\/p>\n

    Most side effects of radiotherapy, including radiotherapy delivered with Accuray systems, are mild and temporary, often involving fatigue, nausea, and skin irritation. Side effects can be severe, however, leading to pain, alterations in normal body functions (for example, urinary or salivary function), deterioration of quality of life, permanent injury, and even death. Side effects can occur during or shortly after radiation treatment or in the months and years following radiation. The nature and severity of side effects depend on many factors, including the size and location of the treated tumor, the treatment technique (for example, the radiation dose), and the patient\u2019s general medical condition, to name a few. For more details about the side effects of your radiation therapy, and to see if treatment with an Accuray product is right for you, ask your doctor. Accuray Incorporated as a medical device manufacturer cannot and does not recommend specific treatment approaches. Individual results may vary.<\/p>\n

    \u00a9 2025 Accuray Incorporated. All Rights Reserved. Accuray, the Accuray logo, and other trademarks are trademarks or registered trademarks of Accuray Incorporated and may not be used without permission. For more information on Accuray and its trademarks, please visit www.accuray.com\/trademarks. MKTRXCSCC160925#2<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

    Goddard LC, Cabrera J, Tang J, Garg MK, Tom\u00e9 WA (Montefiore Medical Center \/ Albert Einstein College of Medicine, NY, USA).<\/p>\n","protected":false},"featured_media":42918,"menu_order":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_links_to":"","_links_to_target":""},"categories":[1866],"studies_products":[],"case_studies_products":[1861,1268],"class_list":["post-42917","studies","type-studies","status-publish","has-post-thumbnail","hentry","category-synchrony-on-radixact","case_studies_products-synchrony","case_studies_products-tomotherapy-radixact"],"acf":[],"yoast_head":"\nPediatric Total Body Irradiation on the Radixact System - Accuray<\/title>\n<meta name=\"description\" content=\"Learn how the Radixact System was used to treat pediatric total body irradiation (TBI) treatment at University Hospitals Birmingham\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.accuray.com\/case-studies\/real-time-adaptive-motion-managementin-prostate-stereotactic-body-radiationtherapy-sbrt-clinical-and-dosimetricanalysis-of-25-patients\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Real-time Adaptive Motion Management In Prostate Stereotactic Body Radiation Therapy (Sbrt): Clinical and Dosimetric Analysis of 25 Patients\" \/>\n<meta property=\"og:description\" content=\"Learn how the Radixact System was used to treat pediatric total body irradiation (TBI) treatment at University Hospitals Birmingham\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.accuray.com\/case-studies\/real-time-adaptive-motion-managementin-prostate-stereotactic-body-radiationtherapy-sbrt-clinical-and-dosimetricanalysis-of-25-patients\/\" \/>\n<meta property=\"og:site_name\" content=\"Accuray\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/AccurayIncorporated\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-24T20:59:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.accuray.com\/wp-content\/uploads\/Montefior_updated_figure.png\" \/>\n\t<meta property=\"og:image:width\" content=\"2012\" \/>\n\t<meta property=\"og:image:height\" content=\"999\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Accuray\" \/>\n<meta name=\"twitter:label1\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data1\" content=\"4\u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.accuray.com\\\/case-studies\\\/real-time-adaptive-motion-managementin-prostate-stereotactic-body-radiationtherapy-sbrt-clinical-and-dosimetricanalysis-of-25-patients\\\/\",\"url\":\"https:\\\/\\\/www.accuray.com\\\/case-studies\\\/real-time-adaptive-motion-managementin-prostate-stereotactic-body-radiationtherapy-sbrt-clinical-and-dosimetricanalysis-of-25-patients\\\/\",\"name\":\"Pediatric Total Body Irradiation on the Radixact System - 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