{"id":43019,"date":"2025-11-20T16:43:43","date_gmt":"2025-11-20T21:43:43","guid":{"rendered":"https:\/\/www.accuray.com\/?post_type=studies&p=43019"},"modified":"2025-11-24T15:57:54","modified_gmt":"2025-11-24T20:57:54","slug":"robotic-stereotactic-body-radiation-therapyfor-high-risk-prostate-cancer-the-georgetownuniversity-experience","status":"publish","type":"studies","link":"https:\/\/www.accuray.com\/ja\/case-studies\/robotic-stereotactic-body-radiation-therapyfor-high-risk-prostate-cancer-the-georgetownuniversity-experience\/","title":{"rendered":"Robotic Stereotactic Body Radiation Therapy For High-risk Prostate Cancer: The Georgetown University Experience"},"content":{"rendered":"\t\t
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\n\t\t\t\t\t\t\t\t\t< View All Case Studies<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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CASE STUDY | MEDSTAR GEORGETOWN UNIVERSITY HOSPITAL<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Robotic Stereotactic Body Radiation Therapy\nFor High-risk Prostate Cancer: The Georgetown\nUniversity Experience<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tDownload Case Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Authors:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tVaibhav Sharma, Tim Kearney, Zach Lee, Padraig Brennan Pilkington, Marielle Fis\nLoperena, Malika Danner, Alan L. Zwart, Deepak Kumar, Brian Collins, Michael\nCarrasquilla, Suy Simeng, Sean Collins \u2013 Medstar Georgetown University Hospital\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Purpose:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tThis retrospective study examines cancer control and health-related\nquality of life (HRQOL) outcomes in high-risk prostate cancer patients\nreceiving robotic stereotactic body radiation therapy (SBRT) with\nSynchrony\u00ae real-time adaptive motion management.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Methods:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Design<\/strong><\/span><\/td>Retrospective analysis of 216 high-risk prostate cancer patients.<\/span><\/td><\/tr>
Treatment<\/strong><\/span><\/td>SBRT on the CyberKnife\u00ae System with Synchrony Fiducial Tracking\u2122. 35\u201336.25 Gy in five fractions over 1-2 weeks. 75% of patients also received androgen deprivation therapy (ADT).<\/span><\/td><\/tr>
Planning<\/strong><\/span><\/td>Three to six gold fiducial markers were placed in the prostate. Fused MR and CT scans were used for treatment planning. The CTV included the prostate, areas of radiographic extracapsular extension, and proximal seminal vesicles. The SBRT-PTV equalled the clinical target volume, spaced 5 mm to the right and left and 3 mm elsewhere.<\/span><\/td>\t\t\t<\/tr>\r\n\t\t<\/tbody>\r\n\r\n\t\t\r\n\t\t\t<\/table>\r\n\t\t<\/div>\r\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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KEY FINDINGS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Cancer Control:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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  • 3-year biochemical disease-free survival (BDFS): 89% (Figure 1).<\/li>
  • Most common recurrence sites: bone (34.15%), PSA-only (24.39%), local (17.08%), abdominal and pelvic nodes (12.2% each) (Figure 2).<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    Cancer Control:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    • Urinary and bowel function scores showed minimal, non-significant declines over 3 years.<\/li>
    • Urinary irritative\/obstructive symptoms slightly improved.<\/li>
    • Bowel symptoms remained low and stable.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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      Figure 1: Biochemical control for high-risk prostate cancer patients receiving SBRT at three-year follow-up<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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      Figure 2: Types of failure in high-risk prostate cancer after five-fraction SBRT, alongside ADT use (yes\/no) for each failure type<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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      Clinical Implications:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      • SBRT was well-tolerated with minimal long-term toxicity.<\/li>
      • Elective pelvic nodal irradiation (ENI) may not be necessary for all high risk prostate cancer patients, as pelvic failures were relatively low (12.2%).<\/li>
      • SBRT offers a convenient, shorter treatment course, especially beneficial for elderly or socioeconomically disadvantaged patients.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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        Conclusion:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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        \u201cDefinitive prostate SBRT for localized high-risk prostate cancer has been shown to yield similar short-term oncologic outcomes to the current standard of care while still affording patients an excellent QOL.\u201d<\/p>

        \u201cWe see non-significant decreases in the gastrointestinal and genitourinary EPIC domain scores, suggesting that this treatment yields minimal long-term toxicity at three-year follow-up.\u201d<\/p>

        \u201cWhile the idea of elective pelvic nodal irradiation remains controversial in the high-risk patient population, our data support local definitive treatment as a favorable option.\u201d<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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        Sharma V, Kearney T, Lee Z, et al. (June 11, 2025) Robotic Stereotactic Body Radiation Therapy for High-Risk Prostate Cancer: The Georgetown University Experience. Cureus 17(6): e85798. doi:10.7759\/cureus.85798<\/p>

        Important Safety Information:<\/p>

        Most side effects of radiotherapy, including radiotherapy delivered with Accuray systems, are mild and temporary, often involving fatigue, nausea, and skin irritation. Side effects can be severe, however, leading to pain, alterations in normal body functions (for example, urinary or salivary function), deterioration of quality of life, permanent injury, and even death. Side effects can occur during or shortly after radiation treatment or in the months and years following radiation. The nature and severity of side effects depend on many factors, including the size and location of the treated tumor, the treatment technique (for example, the radiation dose), and the patient\u2019s general medical condition, to name a few. For more details about the side effects of your radiation therapy, and to see if treatment with an Accuray product is right for you, ask your doctor. Accuray Incorporated as a medical device manufacturer cannot and does not recommend specific treatment approaches. Individual results may vary.<\/p>

        \u00a9 2025 Accuray Incorporated. All Rights Reserved. Accuray, the Accuray logo, and other trademarks are trademarks or registered trademarks of Accuray Incorporated and may not be used without permission. For more information on Accuray and its trademarks, please visit www.accuray.com\/trademarks. MKTCKCSCC17092025#6<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

        This retrospective study examines cancer control and health-related quality of life (HRQOL) outcomes in high-risk prostate cancer patients receiving robotic stereotactic body radiation therapy (SBRT) with Synchrony\u00ae real-time adaptive motion management.<\/p>\n","protected":false},"featured_media":43029,"menu_order":0,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_links_to":"","_links_to_target":""},"categories":[1865],"studies_products":[],"case_studies_products":[1269,1861],"class_list":["post-43019","studies","type-studies","status-publish","has-post-thumbnail","hentry","category-synchrony-on-cyberknife","case_studies_products-cyberknife","case_studies_products-synchrony"],"acf":[],"yoast_head":"\nPediatric Total Body Irradiation on the Radixact System - Accuray<\/title>\n<meta name=\"description\" content=\"Learn how the Radixact System was used to treat pediatric total body irradiation (TBI) treatment at University Hospitals Birmingham\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.accuray.com\/case-studies\/robotic-stereotactic-body-radiation-therapyfor-high-risk-prostate-cancer-the-georgetownuniversity-experience\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Robotic Stereotactic Body Radiation Therapy For High-risk Prostate Cancer: The Georgetown University Experience\" \/>\n<meta property=\"og:description\" content=\"Learn how the Radixact System was used to treat pediatric total body irradiation (TBI) treatment at University Hospitals Birmingham\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.accuray.com\/case-studies\/robotic-stereotactic-body-radiation-therapyfor-high-risk-prostate-cancer-the-georgetownuniversity-experience\/\" \/>\n<meta property=\"og:site_name\" content=\"Accuray\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/AccurayIncorporated\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-24T20:57:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.accuray.com\/wp-content\/uploads\/55405190118011f0a08423eba5a69db0-figure-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"986\" \/>\n\t<meta property=\"og:image:height\" content=\"495\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Accuray\" \/>\n<meta name=\"twitter:label1\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data1\" content=\"4\u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.accuray.com\\\/case-studies\\\/robotic-stereotactic-body-radiation-therapyfor-high-risk-prostate-cancer-the-georgetownuniversity-experience\\\/\",\"url\":\"https:\\\/\\\/www.accuray.com\\\/case-studies\\\/robotic-stereotactic-body-radiation-therapyfor-high-risk-prostate-cancer-the-georgetownuniversity-experience\\\/\",\"name\":\"Pediatric Total Body Irradiation on the Radixact System - 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