30 Years of Evidence

Join the experts’ corner

Take a moment to explore a selection of publications and conference abstracts from around the globe. Find evidence for a wide range of treatment sites including malignant and benign disease, different fractionation schedules and real-time motion synchronization techniques for the CyberKnife® and Radixact®/ TomoTherapy® platforms. We update new papers on a regular basis. See how health professionals are helping to improve patient outcomes.

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Featured Case Studies

Tomotherapy/Radixact

Deep Inspiration Breath Hold Using VitalHold™ on the Radixact® System

A 45-year-old female patient was diagnosed with pT2N1M0 invasive ductal carcinoma of the left breast. The patient underwent breast conservation surgery with axillary dissection, followed by chemotherapy and radiation therapy. Radiation therapy was delivered by the Radixact® System, the latest generation of the TomoTherapy® Platform with surface guided radiotherapy (SGRT)

CyberKnife

Las Vegas CyberKnife® Experience with CyberKnife VOLO™ Optimization: Increase in Patient Throughput & Daily Volumes

Las Vegas CyberKnife worked with Accuray to upgrade their CyberKnife G4 version 9.6 and MultiPlan® version 4.5 to decrease treatment planning times significantly with new planning hardware and optimized software in the first release of Accuray Precision 1.0 and treatment delivery version 11.0.

CyberKnife

The CyberKnife® System Offers Alternative Treatment for Trigeminal Neuralgia

The Hôpital Notre-Dame du CHUM in Montreal, Canada, hosts a monthly clinic for patients with trigeminal neuralgia, a debilitating nerve disorder, that causes “electric” pain in the face. Eating, teeth brushing, shaving or simply a light gust of wind can trigger pain. In 2012, an 89-year-old male patient suffering from

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Publications
Selection of Conference Abstracts

Robotic Stereotactic Body Radiotherapy for Localized Prostate Cancer: Final Analysis of the German Hypostat Trial

David Krug, Detlef Imhoff, Alfred Haidenberger, Nicole Heßler, Jane Schäfer, Stefan Huttenlocher, Georgios Chatzikonstantinou, Christoph Fürweger, Ulla Ramm, Inke R König, Felix Chun, Michael Staehler, Claus Rödel, Alexander Muacevic, Reinhard Vonthein, Jürgen Dunst, Oliver Blanck | Strahlenther Onkol | 2023

Survival and Prognostic Factors of Ultra-Central Tumors Treated with Stereotactic Body Radiotherapy

Salvestrini V, Duijm M, Loi M, Nuyttens JJ | Cancers (Basel) | 2022

Robotic CyberKnife Radiosurgery for the Treatment of Choroidal and Ciliary Body Melanoma

Liegl R, Schmelter V, Fuerweger C, Ehret F, Priglinger S, Muacevic A, Foerster P | Am J Ophthalmol | 2023

Lung Sparing and Ribcage Coverage in Total Body Irradiation Delivered by Helical TomoTherapy

Köksal M, Baumert J, Schoroth F, Scafa D, Koch D, Leitzen C, Sarria GR, Giordano FA, Chatzikonstantinou G, Schmeel LC | Eur J Med Res | 2022

Outcomes of fractionated CyberKnife radiosurgery in patients with choroidal malignant melanoma

Ceyda Baskan, Ebru Atasever Akkas, Sabite Emine Gökce, Sibel Ozdogan | Acta Oncol | 2022

Potential Clinical Significance of Overall Targeting Accuracy and Motion Management in the Treatment of Tumors That Move With Respiration: Lessons Learnt From a Quarter Century of Stereotactic Body Radiotherapy From Dose Response Models – PubMed (nih.gov)

Mahadevan A, Emami B, Grimm J, Kleinberg LR, Redmond KJ, Welsh JS, Rostock R, Kemmerer E, Forster KM, Stanford J, Shah S, Asbell SO, LaCouture TA, Scofield C, Butterwick I, Xue J, Muacevic A, Adler JR | Front Oncol | 2021

Intensity-modulated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): 2-year toxicity results from an open-label, randomised, phase 3, non-inferiority trial

Tree AC, Ostler P, van der Voet H, Chu W, Loblaw A, Ford D, Tolan S, Jain S, Martin A, Staffurth J, Armstrong J, Camilleri P, Kancherla K, Frew J, Chan A, Dayes IS, Duffton A, Brand DH, Henderson D, Morrison K, Brown S, Pugh J, Burnett S, Mahmud M, Hinder V, Naismith O, Hall E, van As N | Lancet Oncol | 2022

Estimation of Annual Secondary Lung Cancer Deaths Using Various Adjuvant Breast Radiotherapy Techniques for Early-Stage Cancers

Jean-Philippe Pignol, Nienke Hoekstra, Derek Wilke, Hannah Dahn, Maureen Nolan, Frank Vicini | Front Oncol | 2021

Skin Toxicity in Early Breast Cancer Patients Treated with Field-In-Field Breast Intensity-Modulated Radiotherapy versus Helical Inverse Breast Intensity-Modulated Radiotherapy: Results of a Phase III Randomised Controlled Trial

K Joseph, L J Vos, Z Gabos, N Pervez, S Chafe, K Tankel, H Warkentin, S Ghosh, J Amanie, K Powell, L-A Polkosnik, S Horsman, M MacKenzie, S Sabri, M B Parliament, J Mackey, B Abdulkarim | Clin Oncol (R Coll Radiol) | 2021

Multi-institutional feasibility study of a fast patient localization method in total marrow irradiation with helical tomotherapy: a global health initiative by the international consortium of total marrow irradiation

Takahashi Y, Vagge S, Agostinelli S, Han E, Matulewicz L, Schubert K, Chityala R, Ratanatharathorn V, Tournel K, Penagaricano JA, Florian S, Mahe MA, Verneris MR, Weisdorf DJ, Corvo R, Dusenbery KE, Storme G, Hui SK | Int J Radiat Oncol Biol Phys | 2015

Fast, simple, and informative patient-specific dose verification method for intensity modulated total marrow irradiation with helical tomotherapy

Takahashi Y, Hui SK | Radiat Oncol | 2014

Extramedullary relapse following total marrow and lymphoid irradiation in patients undergoing allogeneic hematopoietic cell transplantation

Kim JH, Stein A, Tsai N, Schultheiss TE, Palmer J, Liu A, Rosenthal J, Forman SJ, Wong JY | Int J Radiat Oncol Biol Phys | 2014

Total body irradiation in allogeneic bone marrow transplantation conditioning regimens: A review

Paix A, Antoni D, Waissi W, Ledoux MP, Bilger K, Fornecker L, Noel G | Crit Rev Oncol Hematol | 2018

Implementing safe and robust Total Marrow Irradiation using Helical Tomotherapy – A practical guide

Haraldsson A, Engellau J, Lenhoff S, Engelholm S, Bäck S, Engström PE | Phys Med | 2019

Multi-institutional evaluation of MVCT guided patient registration and dosimetric precision in total marrow irradiation: A global health initiative by the international consortium of total marrow irradiation

Zuro D, Vagge S, Broggi S, Agostinelli S, Takahashi Y, Brooks J, Leszcynska P, Liu A, Zucchetti C, Saldi S, Han C, Cattaneo M, Giebel S, Mahe MA, Sanchez JF, Alaei P, Anna C, Dusenbery K, Pierini A, Storme G, Aristei C, Wong JYC, Hui S | Radiother Oncol | 2019