Clinical Evidence

20+ YEARS OF EVIDENCE

Accuray’s radiation therapy technologies build on more than two decades of clinical evidence and real-world use. Don’t take our word for it — hear the proof directly from your expert peers in the publications and videos below:

SRS Treatment

CyberKnife for Brain Metastases

Publications

Sharpton SR, Oermann EK, Moore DT, Schreiber E, Hoffman R, Morris DE, Ewend MG. The volumetric response of brain metastases after stereotactic radiosurgery and its post-treatment implications. 2014 Jan;74(1):9-16.
Pontoriero A, Conti A, Iatì G, Mondello S, Aiello D, Rifatto C, Risoleti E, Mazzei M, Tomasello F, Pergolizzi S, De Renzis C. Prognostic factors in patients treated with stereotactic image-guided robotic radiosurgery for brain metastases: a single-center retrospective analysis of 223 patients. Neurosurg Rev. 2016 Jul;39(3):495-504.
Jiang X, Wang H, Song Y, Wang X, Li F, Dong Y, Wang J, Chen H, Yuan Z. A Second Course of Stereotactic Image-Guided Robotic Radiosurgery for Patients with Cerebral Metastasis. World Neurosurg. 2019 Mar;123:e621-e628.
Lohkamp LN, Vajkoczy P, Budach V, Kufeld M. Efficacy, safety and outcome of frameless image-guided robotic radiosurgery for brain metastases after whole brain radiotherapy. J Neurooncol. 2018 May;138(1):73-81.
Martinage G, Geffrelot J, Stefan D, Bogart E, Rault E, Reyns N, Emery E, Makhloufi-Martinage S, Mouttet-Audouard R, Basson L, Mirabel X, Lartigau E, Pasquier D. Efficacy and Tolerance of Post-operative Hypo-Fractionated Stereotactic Radiotherapy in a Large Series of Patients With Brain Metastases. Front Oncol. 2019 Mar 28;9:184.
Inoue HK, Sato H, Suzuki Y, Saitoh J, Noda SE, Seto K, Torikai K, Sakurai H, Nakano T. Optimal hypofractionated conformal radiotherapy for large brain metastases in patients with high risk factors: a single-institutional prospective study. Radiat Oncol. 2014 Oct 17;9:231.
El Shafie RA, Celik A, Weber D, Schmitt D, Lang K, König L, Bernhardt D, Höne S, Forster T, von Nettelbladt B, Adeberg S, Debus J, Rieken S. A matched‐pair analysis comparing stereotactic radiosurgery with whole‐brain radiotherapy for patients with multiple brain metastases. J Neurooncol. 2020 Apr 1

Videos

Multifraction SRS in the Treatment of Large Brain Oligometastases. Huaguang Zhu M.D., Huashan Hospital in Shanghai.
Multiple Brain Metastases: The Stanford CyberKnife® Experience. Erqi Pollom, M.D., M.S, Stanford University, Stanford, CA, USA.
The Impact of 1-3 vs ≥ 4 Brain Metastases and Patient, Tumor and Imaging Parameters on Overall Survival after CyberKnife® Radiosurgery Judith A. Murovic, MD, Stanford Medical Center – Stanford, CA, USA.
Planning for Multiple Brain Metastases with the CyberKnife® System. Daniela Schmitt Ph.D., Heidelberg University Hospital, Germany.

Posters

3724 Stereotactic Radiotherapy for Brain Metastases using Tomotherapy: 10-Fraction Protocol Reduces Toxicity while Maintaining Efficacy [plan.core-apps.com]

CyberKnife Trigeminal Neuralgia

Publications

Conti A, Acker G, Pontoriero A, Hardt J, Kluge A, Cacciola A, Iatì G, Kufeld M, Budach V, Vajkoczy P, Beltramo G, Pergolizzi S, Bergantin A, Loebel F, Parisi S, Senger C, Romanelli P. Factors affecting outcome in frameless non-isocentric stereotactic radiosurgery for trigeminal neuralgia: a multicentric cohort study. Radiat Oncol. 2020 May 22;15(1):115.
Romanelli P, Conti A, Redaelli I, Martinotti AS, Bergantin A, Bianchi LC, Beltramo G. Cyberknife Radiosurgery for Trigeminal Neuralgia. 2019 Oct 28;11(10):e6014. d.
Romanelli P, Conti A, Bianchi L, Bergantin A, Martinotti A, Beltramo G. Image-Guided Robotic Radiosurgery for Trigeminal Neuralgia. 2018 Nov 1;83(5):1023-1030.

Videos

Image-Guided Robotic Radiosurgery for Trigeminal Neuralgia. Pantaleo Romanelli, M.D. CyberKnife Center, CDI, Milan, Italy.

CyberKnife Acoustic Neuroma & Vestibular Schwannoma

Publications

Windisch PY, Tonn JC, Fürweger C, Wowra B, Kufeld M, Schichor C, Muacevic A. Clinical Results After Single-fraction Radiosurgery for 1,002 Vestibular Schwannomas. Cureus. 2019 Dec 16;11(12):e6390.
Przybylowski CJ, Baranoski JF, Paisan GM, Chapple KM, Meeusen AJ, Sorensen S, Almefty KK, Porter RW. CyberKnife radiosurgery for acoustic neuromas: Tumor control and clinical outcomes. J Clin Neurosci. 2019 May;63:72-76.
Casentini L, Fornezza U, Perini Z, Perissinotto E, Colombo F. Multisession stereotactic radiosurgery for large vestibular schwannomas. J Neurosurg. 2015 Apr;122(4):818-24.

Videos

Clinical Results After Single-fraction Radiosurgery for 1,002 Vestibular Schwannomas Alexander Muacevic, M.D., European CyberKnife Center in Munich, Germany.

CyberKnife Glioma

Publications

Zhang J, Liu Q, Yuan Z, Zhao L, Wang X, Wang P. Clinical Efficacy of CyberKnife Radiosurgery for Adult Brainstem Glioma: 10 Years Experience at Tianjin CyberKnife Center and Review of the Literature. Front Oncol. 2019 Apr 12;9:257.
Repka MC, Lei S, Campbell L, Suy S, Voyadzis JM, Kalhorn C, McGrail K, Jean W, Subramaniam DS, Lischalk JW, Collins SP, Collins BT. Long-Term Outcomes Following Conventionally Fractionated Stereotactic Boost for High-Grade Gliomas in Close Proximity to Critical Organs at Risk. Front Oncol. 2018 Sep 11;8:373.
Pinzi V, Orsi C, Marchetti M, Milanesi IM, Bianchi LC, DiMeco F, Cuccarini V, Farinotti M, Ferroli P, Finocchiaro G, Franzini A, Fumagalli M, Silvani A, Fariselli L. Radiosurgeryreirradiation for high-grade glioma recurrence: a retrospective analysis. Neurol Sci. 2015 Aug;36(8):1431-40.

CyberKnife AVM

Publications

Oermann EK, Murthy N, Chen V, Baimeedi A, Sasaki-Adams D, McGrail K, Collins SP, Ewend MG, Collins BT. A multicenter retrospective study of frameless robotic radiosurgery for intracranial arteriovenous malformation. Front Oncol. 2014 Nov 4;4:298.
Ding C, Solberg TD, Hrycushko B, Medin P, Whitworth L, Timmerman RD. Multi-staged robotic stereotactic radiosurgery for large cerebral arteriovenous malformations. Radiother Oncol. 2013 Dec;109(3):452-6.
Colombo F, Cavedon C, Casentini L, Francescon P, Causin F, Pinna V. Early results of CyberKnife radiosurgery for arteriovenous malformations. J Neurosurg. 2009 Oct;111(4):807-19.

Videos

CyberKnife® Radiosurgery for AVMs: Using High-Definition Rotational Angiographic Imaging. Aditya Gupta M.D. Artemis Hospital in Gurgaon, Delhi NCR, India.

CyberKnife Spinal Metastases

Publications

Pontoriero A, Iatì G, Cacciola A, Conti A, Brogna A, Siragusa C, Ferini G, Davì V, Tamburella C, Molino L, Cambareri D, Severo C, Parisi S, Settineri N, Ielo I, Pergolizzi S. Stereotactic Body Radiation Therapy With Simultaneous Integrated Boost in Patients With Spinal Metastases. Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820904447.
Mehta N, Zavitsanos PJ, Moldovan K, Oyelese A, Fridley JS, Gokaslan Z, Kinsella TJ, Hepel JT. Local failure and vertebral body fracture risk using multifraction stereotactic body radiation therapy for spine metastases. Adv Radiat Oncol. 2018 Apr 10;3(3):245-251.
Azad TD, Esparza R, Chaudhary N, Chang SD. Stereotactic radiosurgery for metastasis to the craniovertebral junction preserves spine stability and offers symptomatic relief. J Neurosurg Spine. 2016 Feb;24(2):241-247.
Gill B, Oermann E, Ju A, Suy S, Yu X, Rabin J, Kalhorn C, Nair MN, Voyadzis JM, Unger K, Collins SP, Harter KW, Collins BT. Fiducial-free CyberKnife stereotactic body radiation therapy (SBRT) for single vertebral body metastases: acceptable local control and normal tissue tolerance with 5 fraction approach. Front Oncol. 2012 Apr 26;2:39.

CyberKnife Spinal AVM

Publications

Kalani MA, Choudhri O, Gibbs IC, Soltys SG, Adler JR, Thompson PA, Tayag AT, Samos CH, Chang SD. Stereotactic radiosurgery for intramedullary spinal arteriovenous malformations. J Clin Neurosci. 2016 Jul;29:162-7.
Rashad S, Endo T, Ogawa Y, Sato K, Endo H, Matsumoto Y, Takahashi A, Tominaga T. Stereotactic radiosurgery as a feasible treatment for intramedullary spinal arteriovenous malformations: a single-center observation. Neurosurg Rev. 2017 Apr;40(2):259-266.
Potharaju M, John R, Venkataraman M, Gopalakrishna K, Subramanian B. Stereotactic radiosurgery results in three cases of intramedullary spinal cord arteriovenous malformations. Spine J. 2014 Nov 1;14(11):2582-8.

TomoTherapy Brain Mets

Publications

Bruni A, Gaito S, Ciarmatori A et al. Radiosurgery Using Tomotherapy for Patients with Brain Oligo-metastasis: A Retrospective Analysis on Feasibility and Tolerance. Anticancer Res. 2015 Dec;35(12):6805-12
Barra A, Agostinello A, Vagge S et al. Radiosurgery with Helical Tomotherapy: Outcomes for Patients with One or Multifocal Brain Metastasis. Technol Cancer Res Treat. 2015 Dec;14(6):693-9
Koide Y, Tomita N, Adachi S et al. Retrospective analysis of hypofractionated stereotactic radiotherapyfor tumors larger than 2 cm. Nagoya J Med Sci. 2019 Aug;81(3):397-406.
Saw CB, Gillette C, Peters CA et al. Clinical implementation of radiosurgery using the Helical TomoTherapy unit. Med Dosim. 2018 Autumn;43(3):284-29
Murai T, Hayashi A, Manabe Y, Sugie C, Takaoka T, Yanagi T, Oguri T, Matsuo M, Mori Y, Shibamoto Y. Efficacy of stereotactic radiotherapy for brain metastases using dynamic jaws technology in the helical tomotherapy system. Br J Radiol. 2016 Oct;89(1066):20160374.

ASTRO/ESTRO 2020 Posters

3724 Stereotactic Radiotherapy for Brain Metastases using Tomotherapy: 10-Fraction Protocol Reduces Toxicity while Maintaining Efficacy [plan.core-apps.com]

CyberKnife Meningioma

Publications

Oh HJ, Cho YH, Kim JH, Kim CJ, Kwon DH, Lee D, Yoon K.J Hypofractionated stereotactic radiosurgery for large-sized skull base meningiomas. Neurooncol. 2020 Aug;149(1):87-93.
Conti A, Senger C, Acker G, Kluge A, Pontoriero A, Cacciola A, Pergolizzi S, Germanò A, Badakhshi H, Kufeld M, Meinert F, Nguyen P, Loebel F, Vajkoczy P, Budach V and Kaul D. Normofractionated stereotactic radiotherapy versus CyberKnife-based hypofractionation in skull base meningioma: a German and Italian pooled cohort analysis. Radiat Oncol. 2019 Nov 12;14(1):201.
Marchetti M, Conti A, Beltramo G, Pinzi V, Pontoriero A, Tramacere I, Senger C, Pergolizzi S, Fariselli L. Multisession radiosurgery for perioptic meningiomas: medium-to-long term results from a CyberKnife cooperative study. J Neurooncol. 2019 Jul;143(3):597-604
Yazici O, Guzle Adas Y, Kekilli E, Calikoglu T, Bedri Altundag M, Riza Ucer A, Ertas G, Durmus Duzgun S, Ozbagi K, Demirkasimoglu A, Demir E, Aslan B, Kaya B. Intracranial meningioma: Experience with stereotactic radiotherapy. J BUON. 2018 Jul-Aug;23(4):1169-1173.
Manabe Y, Murai T, Ogino H, Tamura T, Iwabuchi M, Mori Y, Iwata H, Suzuki H, Shibamoto Y. CyberKnife Stereotactic Radiosurgery and Hypofractionated Stereotactic Radiotherapy As First-line Treatments for Imaging-diagnosed Intracranial Meningiomas. Neurol Med Chir (Tokyo). 2017 Dec 15;57(12):627-633.
Zhang M, Ho AL, D’Astous M, Pendharkar AV, Choi CY, Thompson PA, Tayag AT, Soltys SG, Gibbs IC, Chang SD. CyberKnife Stereotactic Radiosurgery for Atypical and Malignant Meningiomas. World Neurosurg. 2016 Jul;91:574-581.e1.
Oermann EK, Bhandari R, Chen VJ, Lebec G, Gurka M, Lei S, Chen L, Suy S, Azumi N, Berkowitz F, Kalhorn C, McGrail K, Collins BT, Jean WC, Collins SP. Five fraction image-guided radiosurgery for primary and recurrent meningiomas. Front Oncol. 2013 Aug 20;3:213.

SBRT Treatment

CyberKnife Breast

Publications

Rahimi A, Thomas K, Spangler A, Rao R, Leitch M, Wooldridge R, Rivers A, Seiler S, Albuquerque K, Stevenson S, Goudreau S, Garwood D, Haley B, Euhus D, Heinzerling J, Ding C, Gao A, Ahn C, Timmerman R. Preliminary Results of a Phase 1 Dose-Escalation Trial for Early-Stage Breast Cancer Using 5-Fraction Stereotactic Body Radiation Therapy for Partial-Breast Irradiation. Int J Radiat Oncol Biol Phys. 2017 May 1;98(1):196-205.e2.
Mészáros N, Smanykó V, Major T, Stelczer G, Jánváry L, Kovács E, Mária B, Zaka Z, Pukancsik D, Takácsi-Nagy Z, Polgár C. Implementation of Stereotactic Accelerated Partial Breast Irradiation Using Cyber-Knife – Technical Considerations and Early Experiences of a Phase II Clinical Study. Pathol Oncol Res. 2020 Oct;26(4):2307-2313.
Rahimi A, Zhang Y, Kim DW, Morgan H, Hossain F, Leitch M, Wooldridge R, Seiler S, Goudreau S, Haley B, Rao R, Rivers A, Spangler A, Ahn C, Stevenson S, Staley J, Albuquerque K, Ding C, Gu X, Zhao B, Timmerman R. Risk Factors for Fat Necrosis After Stereotactic Partial Breast Irradiation for Early-Stage Breast Cancer in a Phase 1 Clinical Trial. Int J Radiat Oncol Biol Phys. 2020 Nov 1;108(3):697-706.
Lee WH, Chang JS, Kim MJ, Park VY, Yoon JH, Kim SY, Kim JY, Park HS, Kim SI, Cho YU, Park BW, Kim YB. First Experience in Korea of Stereotactic Partial Breast Irradiation for Low-Risk Early-Stage Breast Cancer. Front Oncol. 2020 Apr 29;10:672.
Seiler S, Rahimi A, Choudhery S, Garwood D, Spangler A, Cherian S, Goudreau S. Ultrasound-Guided Placement of Gold Fiducial Markers for Stereotactic Partial-Breast Irradiation. AJR Am J Roentgenol. 2016 Sep;207(3):685-8.
Vermeulen SS, Haas JA. CyberKnife stereotactic body radiotherapy and CyberKnife accelerated partial breast irradiation for the treatment of early breast cancer. Transl Cancer Res 2014;3(4):295-302. doi: 10.3978/j.issn.2218-676X.2014.07.06

Videos

CyberKnife® System Experience for Partial Breast Irradiation. Asal Rahimi M.D. M.S., UT Southwestern Medical Center, Texas, USA.

ASTRO/ESTRO 2020 Posters

Breast poster session (PV 01) – Poster 2035 Three-Year Cosmetic Outcomes of a Phase I Dose Escalation Trial of 5-Fraction Stereotactic Partial Breast Irradiation for Early Stage Breast Cancer [plan.core-apps.com]
Breast poster session (PV 01) – Poster 2042 Stereotactic Body Radiation Therapy for Early-Stage Breast Cancer Using a Robotic Linear Accelerator-Longer Term Results from a Multi-Institutional Trial [plan.core-apps.com]
Breast poster session (PV 01) – Poster 2043 Multi-Institutional Trial of Phase I Dose Escalation Using Single Fraction Stereotactic Partial Breast Irradiation (S-PBI) for Early Stage Breast Cancer [plan.core-apps.com]

CyberKnife Lung

Publications

Unger K, Ju A, Oermann E, Suy S, Yu X, Vahdat S, Subramaniam D, Harter KW, Collins SP, Dritschilo A, Anderson E, Collins BT. CyberKnife for hilar lung tumors: report of clinical response and toxicity. J Hematol Oncol. 2010 Oct 22;3:39.
Lischalk JW, Malik RM, Collins SP, Collins BT, Matus IA, Anderson ED. Stereotactic body radiotherapy (SBRT) for high-risk central pulmonary metastases. Radiat Oncol. 2016 Feb 27;11:28.
Sharma A, Duijm M, Oomen-de Hoop E, Aerts JG, Verhoef C, Hoogeman M, Nuyttens JJ. Factors affecting local control of pulmonary oligometastases treated with stereotactic body radiotherapy. Acta Oncol. 2018 Aug;57(8):1031-1037.
Sumodhee S, Bondiau PY, Poudenx M, Cohen C, Naghavi AO, Padovani B, Maneval D, Gal J, Leysalle A, Ghalloussi H, Otto J, Doyen J. Long term efficacy and toxicity after stereotactic ablative reirradiation in locally relapsed stage III non-small cell lung cancer. BMC Cancer. 2019 Apr 3;19(1):305.
Repka MC, Aghdam N, Kataria SK, Campbell L, Suy S, Collins SP, Anderson E, Lischalk JW, Collins BT. Five-fraction SBRT for ultra-central NSCLC in-field recurrences following high-dose conventional radiation. Radiat Oncol. 2017 Oct 19;12(1):162.

Videos

A Location Dependent Strategy for Treating Lung Tumors with the CyberKnife® System. Cristian Cotrutz, PhD, Swedish Radiosurgery Center, Seattle, WA, USA.
Real-time Tumor Tracking for Lung Cancer: 12 Years of Clinical Outcomes with the CyberKnife® System Jonathan W. Lischalk, M.D., Medstar Georgetown University Hospital, Washington, DC, USA.

CyberKnife Liver

Publications

Anstadt EJ, Shumway R, Colasanto J, Grew D. Single community-based institutional series of stereotactic body radiation therapy (SBRT) for treatment of liver metastases. J Gastrointest Oncol. 2019 Apr;10(2):330-338.
Stintzing S, Einem JV, Fueweger C, Haidenberger A, Fedorov M, Muavcevic A. Long-term Survival in Patients Treated with a Robotic Radiosurgical Device for Liver Metastases. Cancer Res Treat. 2019 Jan;51(1):187-193.
Que J, Lin CH, Lin LC, Ho CH. Challenges of BCLC stage C hepatocellular carcinoma: Results of a single-institutional experience on stereotactic body radiation therapy. Medicine (Baltimore). 2020 Aug 7;99(32):e21561.
Sun J, Wang Q, Hong ZX, Li WG, He WP, Zhang T, Zhang AM, Fan YZ, Sun YZ, Zheng L, Duan XZ. Stereotactic body radiotherapy versus hepatic resection for hepatocellular carcinoma (≤ 5 cm): a propensity score analysis. Hepatol Int. 2020 Sep 4.
Yoon K, Kwak J, Cho B, Park JH, Yoon SM, Lee SW, Kim JH. Gated Volumetric-Modulated Arc Therapy vs. Tumor-Tracking CyberKnife Radiotherapy as Stereotactic Body Radiotherapy for Hepatocellular Carcinoma: A Dosimetric Comparison Study Focused on the Impact of Respiratory Motion Managements. PLoS One. 2016 Nov 22;11(11):e0166927.

Videos

Gated volumetric-modulated arc therapy vs. Tumor-tracking cyberknife radiotherapy as stereotactic body radiotherapy for hepatocellular carcinoma: a dosimetric comparison study focused on the impact of respiratory motion managements. Kyoung Jun Yoon, M.D., Byungchul Cho, M.D., Sang Min Yoon, M.D., Asan Medical Center, Seoul, South Korea.
CyberKnife® Experience for the Treatment of Liver Metastases in a Community Hospital David J. Grew, M.D. | Saint Francis Hospital and Medical Center, Hartford, CT, USA.

CyberKnife Pancreas

Publications

Shen ZT, Zhou H, Li AM, Ji XQ, Jiang CC, Yuan X, Li B, Zhu XX, Huang GC. Clinical outcomes and prognostic factors of stereotactic body radiation therapy combined with gemcitabine plus capecitabine for locally advanced unresectable pancreatic cancer. J Cancer Res Clin Oncol. 2020 Feb;146(2):417-428.
Lischalk JW, Burke A, Chew J, Elledge C, Gurka M, Marshall J, Pishvaian M, Collins S, Unger K. Five-Fraction Stereotactic Body Radiation Therapy (SBRT) and Chemotherapy for the Local Management of Metastatic Pancreatic Cancer. J Gastrointest Cancer. 2018 Jun;49(2):116-123.
Jumeau R, Delouya G, Roberge D, Donath D, Béliveau-Nadeau D, Campeau MP. Stereotactic body radiotherapy (SBRT) for patients with locally advanced pancreatic cancer: A single center experience.Dig Liver Dis. 2018 Apr;50(4):396-400.
Zhu X, Li F, Ju X, Cao F, Cao Y, Fang F, Qing S, Shen Y, Jia Z, Zhang H. Prognostic role of stereotactic body radiation therapy for elderly patients with advanced and medically inoperable pancreatic cancer.Cancer Med. 2017 Oct;6(10):2263-2270.
Lischalk JW, Burke A, Chew J, Elledge C, Gurka M, Marshall J, Pishvaian M, Collins S, Unger K. Five-Fraction Stereotactic Body Radiation Therapy (SBRT) and Chemotherapy for the Local Management of Metastatic Pancreatic Cancer. J Gastrointest Cancer. 2018 Jun;49(2):116-123.
Zeng XL, Wang HH, Meng MB, Wu ZQ, Song YC, Zhuang HQ, Qian D, Li FT, Zhao LJ, Yuan ZY, Wang P. Stereotactic body radiation therapy for patients with recurrent pancreatic adenocarcinoma at the abdominal lymph nodes or postoperative stump including pancreatic stump and other stump. Onco Targets Ther. 2016 Jun 30;9:3985-92.
Dagoglu N, Callery M, Moser J, Tseng J, Kent T, Bullock A, Miksad R, Mancias JD, Mahadevan A. Stereotactic Body Radiotherapy (SBRT) Reirradiation for Recurrent Pancreas Cancer. J Cancer. 2016 Jan 10;7(3):283-8.
Zhang H, Zhao G, Djajaputra D, Xie Y. Determination of acquisition frequency for intrafractional motion of pancreas in CyberKnife radiotherapy. 2014;2014:408019.

Videos

Treatment of Pancreas Cancer with the CyberKnife® System. Anand Mahadevan M.D., Geisinger Medical Center, Danville, Pennsylvania, USA.
Re-irradiation with SBRT for Pancreatic Cancer. Zhang, Huo Jun, M.D., Ph.D. CyberKnife Center, Changhai Hospital, China.

CyberKnife Kidney

Publications

Senger C, Conti A, Kluge A, Pasemann D, Kufeld M, Acker G, Lukas M, Grün A, Kalinauskaite G, Budach V, Waiser J, Stromberger C. Robotic stereotactic ablative radiotherapy for renal cell carcinoma in patients with impaired renal function. BMC Urol. 2019 Oct 21;19(1):96.
S Kaidar-Person O, Price A, Schreiber E, Zagar TM, Chen RC. Stereotactic Body Radiotherapy for Large Primary Renal Cell Carcinoma. Clin Genitourin Cancer. 2017 Oct;15(5):e851-e854.
Ponsky L, Lo SS, Zhang Y, Schluchter M, Liu Y, Patel R, Abouassaly R, Welford S, Gulani V, Haaga JR, Machtay M, Ellis RJ. Phase I dose-escalation study of stereotactic body radiotherapy (SBRT) for poor surgical candidates with localized renal cell carcinoma. Radiother Oncol. 2015 Oct;117(1):183-7.
Staehler M, Bader M, Schlenker B, Casuscelli J, Karl A, Roosen A, Stief CG, Bex A, Wowra B, Muacevic A. Single fraction radiosurgery for the treatment of renal tumors. J Urol. 2015 Mar;193(3):771-5.

CyberKnife Prostate

Publications

Brand DH, Tree AC, Ostler P, van der Voet H, Loblaw A, Chu W, Ford D, Tolan S, Jain S, Martin A, Staffurth J, Camilleri P, Kancherla K, Frew J, Chan A, Dayes IS, Henderson D, Brown S, Cruickshank C, Burnett S, Duffton A, Griffin C, Hinder V, Morrison K, Naismith O, Hall E, van As N; PACE Trial Investigators. Intensity-modulated fractionated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): acute toxicity findings from an international, randomised, open-label, phase 3, non-inferiority trial. Lancet Oncol. 2019 Nov;20(11):1531-1543.
Meier RM, Bloch DA, Cotrutz C, Beckman AC, Henning GT, Woodhouse SA, Williamson SK, Mohideen N, Dombrowski JJ, Hong RL, Brachman DG, Linson PW, Kaplan ID. Multicenter Trial of Stereotactic Body Radiation Therapy for Low- and Intermediate-Risk Prostate Cancer: Survival and Toxicity Endpoints. Int J Radiat Oncol Biol Phys. 2018 Oct 1;102(2):296-303.
Fuller DB, Falchook AD, Crabtree T, Kane BL, Medbery CA, Underhill K, Gray JR, Peddada A, Chen RC. Phase 2 Multicenter Trial of Heterogeneous-dosing Stereotactic Body Radiotherapy for Low- and Intermediate-risk Prostate Cancer: 5-year Outcomes. Eur Urol Oncol. 2018 Dec;1(6):540-547.
Blacksburg SR, Aghdam N, Royce TJ, Burri RJ, Obayomi-Davies O, Mezeckis M, Meier R, Fuller DB, Chen RC, Lanciano RM, Haas JA, Collins SP. 5-year Biochemical Outcomes of Stereotactic Body Radiotherapy with Intraprostatic Dose Escalation for Unfavorable Prostate Cancer. Int J Radiat Oncol Biol Phys. 2019 Sep 8;105(1):E263–E264 (ASTRO 2019)
Wang K, Chen RC, Kane B, Medbery CA, Underhill K, Gray JR, Peddada AV, Fuller DB. Patient and Dosimetric Predictors of Genitourinary and Bowel Quality of Life After Prostate SBRT: Secondary Analysis of a Multi-institutional Trial. Int J Radiat Oncol Biol Phys. 2018 Dec 1;102(5):1430-1437

Videos

Intensity-Modulated Fractionated Radiotherapy versus Stereotactic Body Radiotherapy for Prostate Cancer (PACE-B): Acute Toxicity Findings from an International, Randomised, Open-Label, Phase 3, Non-Inferiority Trial. Nicholas van As M.D., Royal Marsden Hospital, London, UK.
SBRT as a Salvage Option for Localized Recurrent Prostate Cancer. Donald Fuller M.D., Genesis Healthcare Partners, San Diego, CA, USA.
CyberKnife®: the Effect of Intrafraction Rotation as a Predictor of Rectal Toxicity in Prostate SBRT. Seth Blacksburg, M.D., Winthrop Radiology Associates, Mineola, NY.
Building a Prostate SBRT Program with the CyberKnife® System. Jonathan A. Haas, M.D., Winthrop University Hospital, Mineola, NY, USA.
CyberKnife® SBRT for Prostate Cancer: Is 5 better than 44? Olusola Obayomi-Davies M.D., Philadelphia CyberKnife/Crozer Keystone Health System, Havertown, PA, USA.

ASTRO/ESTRO 2020 Posters

Poster session PV 07, poster 3999 10 Year Prostate Stereotactic Body Radiotherapy Outcomes: Relapse-free Survival, PSA Kinetics and Toxicity from a Pooled Analysis of Two Multi-institutional Trials.
Poster session PV 07, poster 4026 Efficacy and Toxicity of Stereotactic Body Radiation Therapy for Localized Prostate Cancer: A Twelve Year Study

TomoTherapy Lung

Publications

Figlia V, Mazzola R, Cuccia F, Alongi F, Mortellaro G, Cespuglio D, Cucchiara T, Iacoviello G, Valenti V, Molino M, Verderame F, Matranga D, Casto AL, Ferrera G. Hypo-fractionated stereotactic radiation therapy for lung malignancies by means of helical tomotherapy: report of feasibility by a single-center experience. Radiol Med. 2018 Jun;123(6):406-414.
Scotti V, Bruni A, Francolini G, Perna M, Vasilyeva P, Loi M, Simontacchi G, Viggiano D, Lanfranchi B, Gonfiotti A, Topulli J, Olmetto E, Maragna V, Ferrari K, Bonti V, Comin C, Balduzzi S, D’Amico R, Lohr F, Voltolini L, Livi L. Stereotactic Ablative Radiotherapy as an Alternative to Lobectomy in Patients With Medically Operable Stage I NSCLC: A Retrospective, Multicenter Analysis. Clin Lung Cancer. 2019 Jan;20(1):e53-e61.

ASTRO/ESTRO 2020 Posters

Poster session PV 02, poster 2576 Lung SBRT Using Helical Tomotherapy: Dosimetric and Delivery Comparison of Dynamic Jaw and Fixed Jaw [plan.core-apps.com]
Poster session PV 02, poster 2711 Going “ITV-Free”: First-in-Clinic Experience with a Real Time Motion Tracking Technique for Lung SBRT Delivery [plan.core-apps.com]

TomoTherapy Mesothelioma

Publications

Hong JH, Lee HC, Choi KH, Moon SW, Kim KS, Hong SH, Hong JY, Kim YS. Preliminary results of entire pleural intensity-modulated radiotherapy in a neoadjuvant setting for resectable malignant mesothelioma. Radiat Oncol J. 2019 Jun;37(2):101-109.
Parisi E, Romeo A, Sarnelli A, Ghigi G, Bellia SR, Neri E, Micheletti S, Dipalma B, Arpa D, Furini G, Burgio MA, Genestreti G, Gurioli C, Sanna S, Bovolato P, Rea F, Storme G, Scarpi E, Arienti C, Tesei A, Polico R. High dose irradiation after pleurectomy/decortication or biopsy for pleural mesothelioma treatment. Cancer Radiother. 2017 Dec;21(8):766-773.

TomoTherapy Liver

Publications

Jung J, Kong M, Hong SE. Conventional fractionated helical tomotherapy for patients with small to medium hepatocellular carcinomas without portal vein tumor thrombosis. Onco Targets Ther. 2014 Sep 26;7:1769-75.
Yoon HI, Lee IJ, Han KH, Seong J. Improved oncologic outcomes with image-guided intensity-modulated radiation therapy using helical tomotherapy in locally advanced hepatocellular carcinoma. J Cancer Res Clin Oncol. 2014 Sep;140(9):1595-605.
Kim JY, Yoo EJ, Jang JW, Kwon JH, Kim KJ, Kay CS. Hypofractionated radiotheapy using helical tomotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis. Radiat Oncol. 2013 Jan 16;8:15.

IG-IMRT Treatment

TomoTherapy Intracranial

Publications

Boulle G, Bracci S, Hitchcock K, Jacob J, Clausse E, Halley A, Belghith B, Kamsu Kom L, Canova CH, Bielle F, Chevalier A, Peyre M, Mazeron JJ, Maingon P, Feuvret L. Treatment of grade II-III intracranial meningioma with helical tomotherapy. J Clin Neurosci. 2019 Jan;59:190-196.

TomoTherapy Head & Neck

Publications

T Liu Z, Xu C, Jiang R, Liu G, Liu Q, Zhou J, Liu F, Yao J, Wang S, Jiang W. Treatment of Locally Advanced Nasopharyngeal Carcinoma by Helical Tomotherapy: An Observational, Prospective Analysis. Transl Oncol. 2019 May;12(5):757-763.
Chitapanarux I, Nobnop W, Sripan P, Chumachote A, Tharavichitkul E, Chakrabandhu S, Klunklin P, Onchan W, Jia-Mahasap B, Janlaor S, Kayan P, Traisathit P, Van Gestel D. The Outcome of the First 100 Nasopharyngeal Cancer Patients in Thailand Treated by Helical Tomotherapy. Radiol Oncol. 2017 Apr 21;51(3):351-356.
Du L, Zhang XX, Feng LC, Qu BL, Chen J, Yang J, Liu HX, Xu SP, Xie CB, Ma L. Propensity score matching analysis of a phase II study on simultaneous modulated accelerated radiation therapy using helical tomotherapy for nasopharyngeal carcinomas. BMC Cancer. 2017 Aug 29;17(1):582.
Du L, Zhang XX, Feng LC, Chen J, Yang J, Liu HX, Xu SP, Xie CB, Ma L. Treatment of nasopharyngeal carcinoma using simultaneous modulated accelerated radiation therapy via helical tomotherapy: a phase II study. Radiol Oncol. 2016 Feb 7;50(2):218-25.
Zhang X, Du L, Zhao F, Wang Q, Yang S, Ma L. A Phase II Clinical Trial of Concurrent Helical Tomotherapy plus Cetuximab Followed by Adjuvant Chemotherapy with Cisplatin and Docetaxel for Locally Advanced Nasopharyngeal Carcinoma. Int J Biol Sci. 2016 Feb 12;12(4):446-53.
Moroney LB, Helios J, Ward EC, Crombie J, Pelecanos A, Burns CL, Spurgin AL, Blake C, Kenny L, Chua B, Hughes BGM. Helical intensity-modulated radiotherapy with concurrent chemotherapy for oropharyngeal squamous cell carcinoma: A prospective investigation of acute swallowing and toxicity patterns. Head Neck. 2018 Sep;40(9):1955-1966.
Bibault JE, Dussart S, Pommier P, Morelle M, Huguet M, Boisselier P, Coche-Dequeant B, Alfonsi M, Bardet E, Rives M, Calugaru V, Chajon E, Noel G, Mecellem H, Servagi Vernat S, Perrier L, Giraud P. Clinical Outcomes of Several IMRT Techniques for Patients With Head and Neck Cancer: A Propensity Score-Weighted Analysis. Int J Radiat Oncol Biol Phys. 2017 Nov 15;99(4):929-937.
Kimura K, Kodaira T, Tomita N, Tachibana H, Makita C, Yoshida M, Nishikawa D, Hirakawa H, Suzuki H, Hanai N, Hasegawa Y. Clinical results of definitive intensity-modulated radiation therapy for oropharyngeal cancer: retrospective analysis of treatment efficacy and safety. Jpn J Clin Oncol. 2016 Jan;46(1):78-85.
Van Gestel D, Van den Weyngaert D, De Kerf G, De Ost B, Vanderveken O, Van Laer C, Specenier P, Geussens Y, Wouters K, Meulemans E, Cheung KJ, Grégoire V, Vermorken JB. Helical tomotherapy in head and neck cancer: a European single-center experience. Oncologist. 2015 Mar;20(3):279-90.

Videos

The Outcome of the First 100 Nasopharyngeal Cancer Patients in Thailand Treated by Helical TomoTherapy®. Imjai Chitapanarux M.D., Chiang Mai University, Thailand.
Clinical Outcomes of Several IMRT Techniques for Patients With Head and Neck Cancer: A Propensity Score-Weighted Analysis. Jean-Emmanuel Bibault, M.D., MSc Georges-Pompidou European Hospital, France.
Impact of Postoperative Daily Image-Guided Intensity-Modulated Radiotherapy on Overall and Local Progression-Free Survival in Patients with Oral Cavity Cancer. Pei-Wei Shueng, MD, Far Eastern Memorial Hospital, Taiwan.

TomoTherapy Breast

Publications

De Paula U, D’Angelilo AM, Andrulli AD et al. Long-Term Outcomes of Once Daily Accelerated Partial Breast Irradiation with Tomotherapy: Results of a Phase II Trial.Int J Radiat Oncol Biol Phys. Article in Press
Joseph K, Vos LJ, Gabos Z, Pervez N, Chafe S, Tankel K, Warkentin H, Ghosh S, Amanie J, Powell K, Polkosnik LA, Horsman S, MacKenzie M, Sabri S, Parliament MB, Mackey J, Abdulkarim B. Skin Toxicity in Early Breast Cancer Patients Treated with Field-In-Field Breast Intensity-Modulated Radiotherapy versus Helical Inverse Breast Intensity-Modulated Radiotherapy: Results of a Phase III Randomised Controlled Trial. Clin Oncol (R Coll Radiol). 2020 Jul 22:S0936-6555(20)30287-9.
Chitapanarux I, Nobnop W, Tippanya D, Sripan P, Chakrabandhu S, Klunklin P, Onchan W, Jia-Mahasap B, Tharavichitkul E. Clinical outcomes and dosimetric study of hypofractionated Helical TomoTherapy in breast cancer patients. PLoS One. 2019 Jan 31;14(1):e0211578.
Arsene-Henry A, Foy JP, Robilliard M, Xu HP, Bazire L, Peurien D, Poortmans P, Fourquet A, Kirova YM. The use of helical tomotherapy in the treatment of early stage breast cancer: indications, tolerance, efficacy-a single center experience. Oncotarget. 2018 May 4;9(34):23608-23619.
Orecchia R, Rojas DP, Cattani F, Ricotti R, Santoro L, Morra A, Cambria R, Luraschi R, Dicuonzo S, Ronchi S, Surgo A, Dell’ Acqua V, Veronesi P, De Lorenzi F, Fodor C, Leonardi MC, Jereczek-Fossa BA. Hypofractionated postmastectomy radiotherapy with helical tomotherapy in patients with immediate breast reconstruction: dosimetric results and acute/intermediate toxicity evaluation. Med Oncol. 2018 Feb 13;35(3):39.
Thery L, Arsene-Henry A, Carroll S, Peurien D, Bazire L, Robilliard M, Fourquet A, Kirova YM. Use of helical tomotherapy in locally advanced and/or metastatic breast cancer for locoregional treatment. Br J Radiol. 2018 May;91(1085):20170822.
Mathieu D, Bedwani S, Mascolo-Fortin J, Côté N, Bernard AA, Roberge D, Yassa M, Bahig H, Vu T. Cardiac Sparing with Personalized Treatment Planning for Early-stage Left Breast Cancer. 2020 Mar 12;12(3):e7247.
Joseph K, Vos LJ, Gabos Z, Pervez N, Chafe S, Tankel K, Warkentin H, Ghosh S, Amanie J, Powell K, Polkosnik LA, Horsman S, MacKenzie M, Sabri S, Parliament MB, Mackey J, Abdulkarim B. Skin Toxicity in Early Breast Cancer Patients Treated with Field-In-Field Breast Intensity-Modulated Radiotherapy versus Helical Inverse Breast Intensity-Modulated Radiotherapy: Results of a Phase III Randomised Controlled Trial. Clin Oncol (R Coll Radiol). 2020 Jul 22:S0936-6555(20)30287-9.

Videos

TomoTherapy for Breast Cancer in a Clinical Setting. Samantha Dicuonzo M.D. & Raffaella Cambria M.Sc., European Institute of Oncology, Milan, Italy.
Clinical Outcomes and Dosimetric Study of Hypofractionated Helical TomoTherapy® in Breast Cancer Patients. Imjai Chitapanarux M.D. Chiang Mai University, Thailand.
A Comprehensive Radiotherapy Strategy for Managing Breast Cancer. Rupesh Kotecha, M.D., Miami Cancer Institute, Miami FL, USA.
Breast Cancer: Your Challenges Today – Our Solutions for Tomorrow. Nathan Corradini, MS, DABR, SSRMP, Clinica Luganese, Lugano, Switzerland, Carole Massabeau, M.D., Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France, Jennifer R. Bellon, M.D. Dana-Farber Cancer Institute, Boston, MA, USA.
Benefits of TomoDirect™ to Treat Breast Cancer. Nathan Corradini, MS, DABR, SSRMP | Clinica Luganese – Lugano, Switzerland.
Using the Tomotherapy® System for Whole Breast Irradiation in the Community Clinic Setting. Robert A. Harris, M.D., Gamma West, Layton, UT, USA.

ASTRO/ESTRO 2020 Posters

Breast poster session (PV 01) – Poster 2036 Long-Term Outcomes of Once Daily Accelerated Partial Breast Irradiation with TomoTherapy: Phase II Trial Results on 338 Women Treated at a Single Institution [plan.core-apps.com]
Breast poster session (PV 01) – Poster 2071 Long-Term Risks of Secondary Cancer for Various Whole Breast Irradiation Techniques, Including Helical IMRT [plan.core-apps.com]

TomoTherapy Lung

Publications

Vekens K, Verbanck S, Collen C, Storme G, Barbé K, De Ridder M, Vanderhelst E. Pulmonary function changes following helical tomotherapy in patients with inoperable, locally advanced non-small cell lung cancer. Strahlenther Onkol. 2020 Feb;196(2):142-150.

TomoTherapy Mesothelioma

Publications

Harrabi SB, Koerber SA, Adeberg S, Katayama S, Herfarth K, Debus J, Sterzing F. Malignant pleural mesothelioma – Pleural cavity irradiation after decortication with helical tomotherapy. Rep Pract Oncol Radiother. 2017 Sep-Oct;22(5):402-407.
Kishan AU, Cameron RB, Wang PC, Alexander S, Qi SX, Low DA, Kupelian PA, Steinberg ML, Lee JM, Selch MT, Lee P. Tomotherapy improves local control and changes failure patterns in locally advanced malignant pleural mesothelioma. Pract Radiat Oncol. 2015 Nov-Dec;5(6):366-73.

TomoTherapy Prostate

Publications

Macias VA, Barrera-Mellado I. Ultra-hypofractionated radiation therapy for unfavourable intermediate-risk and high-risk prostate cancer is safe and effective: 5-year outcomes of a phase II trial. BJU Int. 2019 Oct 15. doi: 10.1111/bju.14925.
Di Muzio NG, Fodor A, Noris Chiorda B, Broggi S, Mangili P, Valdagni R, Dell’Oca I, Pasetti M, Deantoni CL, Chiara A, Berardi G, Briganti A, Calandrino R, Cozzarini C, Fiorino C. Moderate Hypofractionation with Simultaneous Integrated Boost in Prostate Cancer: Long-term Results of a Phase I-II Study. Clin Oncol (R Coll Radiol). 2016 Aug;28(8):490-500.
Tomita N, Soga N, Ogura Y, Hayashi N, Kageyama T, Ito M, Koide Y, Yoshida M, Kimura K, Makita C, Tachibana H, Kodaira T. High-dose radiotherapy with helical tomotherapy and long-term androgen deprivation therapy for prostate cancer: 5-year outcomes. J Cancer Res Clin Oncol. 2016 Jul;142(7):1609-19.
Yamazaki H, Masui K, Suzuki G, Nakamura S, Shimizu D, Nishikawa T, Okabe H, Yoshida K, Kotsuma T, Tanaka E, Otani K, Yoshioka Y, Ogawa K. High-Dose-Rate Brachytherapy Monotherapy versus Image-Guided Intensity-Modulated Radiotherapy with Helical Tomotherapy for Patients with Localized Prostate Cancer. Cancers (Basel). 2018 Sep 10;10(9):322.

Videos

Safe and Effective Stereotactic Body Radiation Therapy (SBRT) for High-Risk Prostate Cancer Patients: 4-year Outcomes of a Phase II Trial. Victor Macias Hernandez, M.D., Ph.D. Salamanca University Hospital; Valladolid University Hospital,

TomoTherapy Rectal Cancer

Publications

De Bari B, Franzetti-Pellanda A, Saidi A, Biggiogero M, Hahnloser D, Montemurro M, Bourhis J, Zeverino M, Ozsahin M. Neoadjuvant chemoradiotherapy delivered with helical tomotherapy under daily image guidance for rectal cancer patients: efficacy and safety in a large, multi-institutional series. J Cancer Res Clin Oncol. 2019 Apr;145(4):1075-1084.
Zhao J, Liu X, Wang W, Hu K, Zhang F, Hou X, Meng Q. Concomitant dose escalation with image-guided Tomotherapy in locally advanced mid-low rectal cancer: a single-center study. Cancer Manag Res. 2019 Feb 15;11:1579-1586.
Huang CM, Huang MY, Tsai HL, Huang CW, Ma CJ, Lin CH, Huang CJ, Wang JY. A retrospective comparison of outcome and toxicity of preoperative image-guided intensity-modulated radiotherapy versus conventional pelvic radiotherapy for locally advanced rectal carcinoma. J Radiat Res. 2017 Mar 1;58(2):247-259.

Videos

Role of the TomoTherapy® System in the Treatment of Rectal Cancer. Berardino De Bari M.D., University Hospital of Besançon, France.
TomoTherapy® for Advanced Rectal Cancer. Xiaoliang Liu, M.D., Peking Union Medical College Hospital, Beijing, China.

TomoTherapy Anal Cancer

Publications

Klausner G, Blais E, Jumeau R, Biau J, de Meric de Bellefon M, Ozsahin M, Zilli T, Miralbell R, Thariat J, Troussier I. Management of locally advanced anal canal carcinoma with intensity-modulated radiotherapy and concurrent chemotherapy. Med Oncol. 2018 Aug 20;35(10):134.
De Bari B, Lestrade L, Franzetti-Pellanda A, Jumeau R, Biggiogero M, Kountouri M, Matzinger O, Miralbell R, Bourhis J, Ozsahin M, Zilli T. Modern intensity-modulated radiotherapy with image guidance allows low toxicity rates and good local control in chemoradiotherapy for anal cancer patients. J Cancer Res Clin Oncol. 2018 Apr;144(4):781-789.
Joseph K, Vos LJ, Warkentin H, Paulson K, Polkosnik LA, Usmani N, Tankel K, Severin D, Nijjar T, Schiller D, Wong C, Ghosh S, Mulder K, Field C. Patient reported quality of life after helical IMRT based concurrent chemoradiation of locally advanced anal cancer. Radiother Oncol. 2016 Aug;120(2):228-33.
Koerber SA, Slynko A, Haefner MF, Krug D, Schoneweg C, Kessel K, Kopp-Schneider A, Herfarth K, Debus J, Sterzing F. Efficacy and toxicity of chemoradiation in patients with anal cancer–a retrospective analysis. Radiat Oncol. 2014 May 13;9:113.

TomoTherapy Bladder

Publications

Murthy V, Gupta P, Baruah K, Krishnatry R, Joshi A, Prabhash K, Noronha V, Menon S, Pal M, Prakash G, Bakshi G. Adaptive Radiotherapy for Carcinoma of the Urinary Bladder: Long-term Outcomes With Dose Escalation. Clin Oncol (R Coll Radiol). 2019 Sep;31(9):646-652.

TomoTherapy Sarcoma

Publications

Salfelder MA, Kessel KA, Thiel U, Burdach S, Kampfer S, Combs SE. Prospective evaluation of multitarget treatment of pediatric patients with helical intensity-modulated radiotherapy. Strahlenther Onkol. 2020 Aug 3.
Peeken JC, Knie C, Kessel KA, Habermehl D, Kampfer S, Dapper H, Devecka M, von Eisenhart-Rothe R, Specht K, Weichert W, Wörtler K, Knebel C, Wilkens JJ, Combs SE. Neoadjuvant image-guided helical intensity modulated radiotherapy of extremity sarcomas – a single center experience. Radiat Oncol. 2019 Jan 9;14(1):2.

Long Fields Treatment

TomoTherapy Total Body Irradiation

Publications

Wilhelm-Buchstab T, Leitzen C, Schmeel LC, Simon B, Koch D, Schmeel FC, Schoroth F, Garbe S, Röhner F, Wolf D, Schüller H, Schild HH, Müdder T. Total body irradiation: Significant dose sparing of lung tissue achievable by helical tomotherapy. Z Med Phys. 2020 Feb;30(1):17-23.
Paix A, Antoni D, Waissi W, Ledoux MP, Bilger K, Fornecker L, Noel G. Total body irradiation in allogeneic bone marrow transplantation conditioning regimens: A review. Crit Rev Oncol Hematol. 2018 Mar;123:138-148.
Sarradin V, Simon L, Huynh A, Gilhodes J, Filleron T, Izar F. Total body irradiation using Helical Tomotherapy^®: Treatment technique, dosimetric results and initial clinical experience. Cancer Radiother. 2018 Feb;22(1):17-24.
Gruen A, Ebell W, Wlodarczyk W, Neumann O, Kuehl JS, Stromberger C, Budach V, Marnitz S. Total Body Irradiation (TBI) using Helical Tomotherapy in children and young adults undergoing stem cell transplantation. Radiat Oncol. 2013 Apr 15;8:92.
Chao M, Penagaricano J, Yan Y, Moros EG, Corry P, Ratanatharathorn V. Voxel-based dose reconstruction for total body irradiation with helical tomotherapy. Int J Radiat Oncol Biol Phys. 2012 Apr 1;82(5):1575-83.

Videos

Russian Experience of using Helical TomoTherapy for Total Body Irradiation in Wide Heterogenic Cohort of 262 Pediatric Patients with Hematological Malignancies. Daria Kobyzeva M.D. & Anna Loginova M.S, Dmitry Rogachev National Medical Research Center, Moscow, Russia.

TomoTherapy Total Marrow Irradiation

Publications

Zuro D, Vagge S, Broggi S, Agostinelli S, Takahashi Y, Brooks J, Leszcynska P, Liu A, Zucchetti C, Saldi S, Han C, Cattaneo M, Giebel S, Mahe MA, Sanchez JF, Alaei P, Anna C, Dusenbery K, Pierini A, Storme G, Aristei C, Wong JYC, Hui S. Multi-institutional evaluation of MVCT guided patient registration and dosimetric precision in total marrow irradiation: A global health initiative by the international consortium of total marrow irradiation. Radiother Oncol. 2019 Dec;141:275-282.
Haraldsson A, Engellau J, Lenhoff S, Engelholm S, Bäck S, Engström PE. Implementing safe and robust Total Marrow Irradiation using Helical Tomotherapy – A practical guide. Phys Med. 2019 Apr;60:162-167. D
Paix A, Antoni D, Waissi W, Ledoux MP, Bilger K, Fornecker L, Noel G. Total body irradiation in allogeneic bone marrow transplantation conditioning regimens: A review. Crit Rev Oncol Hematol. 2018 Mar;123:138-148.
Takahashi Y, Vagge S, Agostinelli S, Han E, Matulewicz L, Schubert K, Chityala R, Ratanatharathorn V, Tournel K, Penagaricano JA, Florian S, Mahe MA, Verneris MR, Weisdorf DJ, Corvo R, Dusenbery KE, Storme G, Hui SK. Multi-institutional feasibility study of a fast patient localization method in total marrow irradiation with helical tomotherapy: a global health initiative by the international consortium of total marrow irradiation. Int J Radiat Oncol Biol Phys. 2015 Jan 1;91(1):30-8.
Kim JH, Stein A, Tsai N, Schultheiss TE, Palmer J, Liu A, Rosenthal J, Forman SJ, Wong JY. Extramedullary relapse following total marrow and lymphoid irradiation in patients undergoing allogeneic hematopoietic cell transplantation. Int J Radiat Oncol Biol Phys. 2014 May 1;89(1):75-81.
Takahashi Y, Hui SK. Fast, simple, and informative patient-specific dose verification method for intensity modulated total marrow irradiation with helical tomotherapy. Radiat Oncol. 2014 Jan 25;9:34.

Videos

From TBI to TMI for Advanced Onco-Hematological Diseases. Stefano Vagge M.D. Ph.D. IRCCS Policlinico San Martino, Genova, Italy.
Total Marrow Irradiation with TomoTherapy®: Redefining the Role of Radiation Therapy in Hematopoietic Cell Transplantation. Jeffrey Wong M. D. & An Liu Ph.D., City of Hope, Duarte, CA, USA.

ASTRO/ESTRO 2020 Posters

1082 Phase II Study of Dose Escalated Total Marrow and Lymphoid Irradiation (TMLI) in Combination with Cyclophosphamide and Etoposide in Patients with Poor-Risk Acute Leukemia [plan.core-apps.com]

Total Skin Irradiation

Publications

Haraldsson A, Engleson J, Bäck SÅJ, Engelholm S, Engström PE. A Helical tomotherapy as a robust low-dose treatment alternative for total skin irradiation. J Appl Clin Med Phys. 2019 May;20(5):44-54.
Hsieh CH, Tien HJ, Yu YB, Wu YH, Shueng PW, Lu YF, Wang SY, Wang LY. Simultaneous integrated boost with helical arc radiotherapy of total skin (HEARTS) to treat cutaneous manifestations of advanced, therapy-refractory cutaneous lymphoma and leukemia – dosimetry comparison of different regimens and clinical application. Radiat Oncol. 2019 Jan 28;14(1):17.
Hsieh CH, Shueng PW, Lin SC, Tien HJ, Shiau AC, Chou YH, Wu MH, Wang JY, Chen CK, Chen YJ. Helical irradiation of the total skin with dose painting to replace total skin electron beam therapy for therapy-refractory cutaneous CD4+ T-cell lymphoma. Biomed Res Int. 2013;2013:717589.

TomoTherapy Pediatrics

Publications

Salfelder MA, Kessel KA, Thiel U, Burdach S, Kampfer S, Combs SE. Prospective evaluation of multitarget treatment of pediatric patients with helical intensity-modulated radiotherapy. Strahlenther Onkol. 2020 Aug 3.
Chen GY, Cheng JC, Chen YH, Lu MY, Chang HH, Yang YL, Jou ST, Hsu WM, Kuo SH. Local Control and Clinical Outcome of High-risk Pediatric Neuroblastoma Patients After Receiving Multimodality Treatment and Helical Tomotherapy. Anticancer Res. 2019 Apr;39(4):2207-2215.
Scobioala S, Parfitt R, Matulat P, Kittel C, Ebrahimi F, Wolters H, Am Zehnhoff-Dinnesen A, Eich HT. Impact of radiation technique, radiation fraction dose, and total cisplatin dose on hearing : Retrospective analysis of 29 medulloblastoma patients. Strahlenther Onkol. 2017 Nov;193(11):910-920.
Schiopu SR, Habl G, Häfner M, Katayama S, Herfarth K, Debus J, Sterzing F. Craniospinal irradiation using helical tomotherapy for central nervous system tumors. J Radiat Res. 2017 Mar 1;58(2):238-246.
Peñagarícano J, Moros E, Corry P, Saylors R, Ratanatharathorn V. Pediatric craniospinal axis irradiation with helical tomotherapy: patient outcome and lack of acute pulmonary toxicity. Int J Radiat Oncol Biol Phys. 2009 Nov 15;75(4):1155-61.
Zhang X, Ma K, Wang J, Wu W, Ma L, Huang D. A prospective evaluation of the combined helical tomotherapy and chemotherapy in pediatric patients with unresectable rhabdomyosarcoma of the temporal bone. Cell Biochem Biophys. 2014 Sep;70(1):103-8.

Videos/Slides

Russian Experience of using Helical TomoTherapy for Total Body Irradiation in Wide Heterogenic Cohort of 262 Pediatric Patients with Hematological Malignancies. Daria Kobyzeva M.D. & Anna Loginova M.S, Dmitry Rogachev National Medical Research Center, Moscow, Russia.
What Does the TomoTherapy® System Bring to Pediatric Treatment Challenges? Anne Laprie, M.D., Ph.D. – IUCT Oncopole, Toulouse, France.
VLADI: An alternative to anesthesia in radiotherapy treatments. Ana Roma Calçarão, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Moving Targets Treatment

Motion Synchronization on CyberKnife

Publications

Hoogeman M, Prévost JB, Nuyttens J, Pöll J, Levendag P, Heijmen B. Clinical accuracy of the respiratory tumor tracking system of the cyberknife: assessment by analysis of log files. Int J Radiat Oncol Biol Phys. 2009 May 1;74(1):297-303.
Pepin EW, Wu H, Zhang Y, Lord B. Correlation and prediction uncertainties in the cyberknife synchrony respiratory tracking system. Med Phys. 2011 Jul;38(7):4036-44
Nakayama M, Nishimura H, Mayahara H et al. Clinical log data analysis for assessing the accuracy of the CyberKnife fiducial-free lung tumor tracking system. Pract Radiat Oncol. 2018 Mar – Apr;8(2):e63-e70

Videos/Slides

Dynamic Tracking and Motion Correction: Over 15 Years of Accuray Leadership featuring
- Clinical Value of Motion Synchronization for Lung SBRT. Jonathan W. Lischalk, M.D., Medstar Georgetown University Hospital, Washington, DC, USA.
- Clinical Value of Motion Synchronization for Prostate SBRT. Ronald Chen, M.D. M.P.H., University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
CyberKnife® System with Fiducial Tracking Mature Outcomes. Brian T. Collins, M.D., MedStar Georgetown University Hospital, Washington, DC, USA.

For more indication specific information, view the SBRT section.

Motion Synchronization on Radixact

Publications

Ferris WS, Culberson WS. Technical note: Patient dose from kilovoltage radiographs during motion-synchronized treatments on radixact. Med Phys. 2020 Sep 18.
Ferris WS, Kissick MW, Bayouth JE, Culberson WS, Smilowitz JB. Evaluation of radixact motion synchrony for 3D respiratory motion: Modeling accuracy and dosimetric fidelity. J Appl Clin Med Phys. 2020 Sep;21(9):96-106.
Chen GP, Tai A, Keiper TD, Lim S, Li XA. Technical Note: Comprehensive performance tests of the first clinical real-time motion tracking and compensation system using MLC and jaws. Med. Phys. 47 (7), July 2020.
Price A, Chen J, Chao E, Schnarr E, Schreiber E, Lu L, Cox A, Chang S, Jian J. Compensation of intrafractional motion for lung stereotactic body radiotherapy (SBRT) on helical TomoTherapy. Phys. Eng. Express 2019;5:025043.
Chao EH, Lucas D, Schnarr E. Evaluation of TomoTherapy dose calculations with intrafractional motion and motion compensation. Med Phys. 2018 Jan;45(1):18-28.
Schnarr E, Beneke M, Casey D, Chao E, Chappelow J, Cox A, Henderson D, Jordan P, Lessard E, Lucas D, Myronenko A, Mauer C. Feasibility of real-time motion management with helical tomotherapy. Med Phys. 2018 Apr;45(4):1329-1337.

Videos

Comprehensive Performance Tests of the First Clinical Real-Time Motion Tracking and Compensation System Using MLC and Jaws. Guang-Pei Chen Ph.D., Medical College of Wisconsin, Milwaukee, WI, USA.
Dynamic Tracking and Motion Correction: Over 15 Years of Accuray Leadership featuring QA Testing of Motion Tracking with Synchrony^® Allen Li, PhD, DABMP, FAAPM, Medical College of Wisconsin, Milwaukee, WI, USA.
Validating Synchrony® on the Radixact^® System for Respiratory Motion. John E. Bayouth, Ph.D, UW-Madison School of Medicine and Public Health, Madison, WI, USA.

ASTRO/ESTRO 2020 Posters

Poster session PV 02, poster 2575 Clinical Implementation of Real-time Motion Tracking with Jaws and MLC during Helical Tomotherapy Delivery [plan.core-apps.com]
Poster session PV 02, poster 2711 Going “ITV-Free”: First-in-Clinic Experience with a Real Time Motion Tracking Technique for Lung SBRT Delivery [plan.core-apps.com]

20+ YEARS OF EVIDENCE

SRS Treatment

CyberKnife for Brain Metastases

CyberKnife Trigeminal Neuralgia

CyberKnife Acoustic Neuroma & Vestibular Schwannoma

CyberKnife Glioma

CyberKnife AVM

CyberKnife Spinal Metastases

CyberKnife Spinal AVM

TomoTherapy Brain Mets

CyberKnife Meningioma

SBRT Treatment

CyberKnife Breast

CyberKnife Lung

CyberKnife Liver

CyberKnife Pancreas

CyberKnife Kidney

CyberKnife Prostate

TomoTherapy Lung

TomoTherapy Mesothelioma

TomoTherapy Liver

IG-IMRT Treatment

TomoTherapy Intracranial

TomoTherapy Head & Neck

TomoTherapy Breast

TomoTherapy Lung

TomoTherapy Mesothelioma

TomoTherapy Prostate

TomoTherapy Rectal Cancer

TomoTherapy Anal Cancer

TomoTherapy Bladder

TomoTherapy Sarcoma

Long Fields Treatment

TomoTherapy Total Body Irradiation

TomoTherapy Total Marrow Irradiation

Total Skin Irradiation

TomoTherapy Pediatrics

Moving Targets Treatment

Motion Synchronization on CyberKnife

Motion Synchronization on Radixact

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