Radiation Therapy for Lung Cancer with CyberKnife® System

AI-driven, real-time respiratory motion synchronization for unmatched precision

Revolutionary Synchrony® Motion Synchronization technology powers radically precise, highly effective non-surgical stereotactic body radiation therapy treatments for lung cancer regardless of tumor complexity and location.

Precise robotic SBRT lung cancer treatment as individual as every patient

CyberKnife® therapy for lung cancer combines advanced robotic treatment and the world’s only real-time, AI-driven motion synchronization technology to dynamically synchronize stereotactic body radiation therapy treatment delivery with natural respiration, enabling the clinical team to deliver high doses of radiation with extreme precision while providing the patient with a personalized treatment.

Motion Synchronization and Delivery Adaptation

CyberKnife lung cancer treatment provides a fully integrated image-guidance system that continually acquires stereoscopic kV images during treatment, tracks motion and leverages advanced AI to automatically synchronize the treatment beam alignment in real-time. The 6-axis robotic arm aims each treatment beam taking into account tumor motion throughout treatment delivery. All measured displacements are automatically corrected, regardless of how small, maintaining sub-millimeter accuracy1.

Synchronized with natural breathing

A lung tumor will continuously move throughout the course of treatment delivery. Unlike any other radiation therapy device, CyberKnife lung cancer treatment uses the world’s only real-time motion synchronization technology to continuously track that motion and adapt treatment delivery to maintain sub-millimeter precision. This potentially helps to ensure the radiation dose is delivered to the target — maximizing treatment effectiveness while minimizing dose to surrounding tissues to help reduce the incidence of certain side effects. And unlike other radiotherapy options, the CyberKnife System does not require uncomfortable patient restraints or breath-hold techniques; you can relax and breathe normally, with full confidence in the CyberKnife’s synchronization capabilities.

CyberKnife chest wall

Sharp dose gradient

The robotic design of the CyberKnife System seamlessly delivers non-coplanar, non-isocentric and isocentric beams from a wide range of angles. These unique delivery capabilities sculpt conformal dose distributions and enable precise and effective treatments regardless of the target complexity and location. Sharp dose gradients provided by the system for lung treatments minimize dose to critical structures and reduce the total dose of radiation to the lung as measured by V20 and V5 calculations in comparison to standard motion management techniques. Dose-volume histogram (DVH) parameters, such as lung V20 and V5, play an important role in radiation treatment planning for thoracic malignancies including pulmonary toxicity risk prediction.

Validated accuracy

CyberKnife therapy for lung cancer uses proprietary anatomy-specific algorithms to track tumor motion. Synchrony Respiratory Modeling is used for lung treatments and allows the patient to lie on the treatment couch and breathe naturally without the need for restraints, breath holding techniques, or gating. Academic institutions have independently validated the total accuracy of this modality to be even better than Accuray’s industry leading sub-millimeter specification of performance.


  • 0.95 mm (Accuray specification)
  • < 0.6 mm7

Versatility in collimator options

The CyberKnife System offers a collection of available collimators, providing the versatility needed to treat a wide range of lung tumors.

  • Fixed Circular Collimators
  • Iris Variable Aperture Collimator
  • InCise Multileaf Collimator

Demonstrated clinical benefits

The CyberKnife System enables effective SBRT for central lung tumors surrounded by sensitive structures2 and lung tumors near the chest wall3. It also provides excellent clinical outcomes for patients with inoperable peripheral lung tumors4-6. Furthermore, a pooled analysis of two randomized trials indicates that lung SBRT is better tolerated and might lead to better overall survival compared to surgery for operable early-state lung cancer7.

CyberKnife central lung

Clinical Examples

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CyberKnife System Accuracy:

1) Muacevic A. et. al. “Technical Description, Phantom Accuracy, and Clinical Feasibility for Single-session Lung Radiosurgery Using Robotic Image-guided Real-time Respiratory Tumor Tracking” TCRT. 2007; 6(4): 321-328 – https://doi.org/10.1177/153303460700600409


2) Nuyttens J.J. et al. “Outcome of four-dimensional stereotactic radiotherapy for centrally located long tumors” Radiotherapy and Oncology. 2012; 102: 383-387

3) Podder T. et al. “Chest wall and rib irradiation and toxicities of early-stage lung cancer patients treated with CyberKnife stereotactic body radiotherapy.” Future oncology. 2014; 10(15): 2311-2317

4) Brown W.T. et al. “Application of robotic stereotactic radiotherapy to peripheral state I non-small cell lung cancer with curative intent.” Clin Oncol (R Coll Radiol). 2009; 21: 623-631

5) Snider J.W. et al. “CyberKnife with tumor tracking: an effective treatment for high-risk surgical patients with single peripheral lung metastases” Front Oncol. 2012; 2: 63 – https://doi.org/10.3389/fonc.2012.00063

6) Lischalk J.W. et al. “Long-term outcomes of stereotactic body radiation therapy (sbrt) with fiducial tracking for inoperable stage I non-small cell lung cancer (nsclc).” J Radiat Oncol. 2016; 5: 379-387 – https://doi.org/10.1007/s13566-016-0273-4

7) Chang S. et al. “Stereotactic ablative radiotherapy versus lobectomy for opereable stage I non-small-cell lung cancer: a pooled analysis of two rancomised trials.” Lancet Oncol. 2015; 16(6) 630-637 – https://doi.org/10.1111/1759-7714.12574

Technology naming information:

In April 2020 Accuray expanded the use of the Synchrony® brand name. As such, please be advised that the names for motion tracking and correction algorithms referenced in clinical publications may be different that current naming. Below you will find information on those name changes so that you may find the appropriate reference in existing clinical literature:

Synchrony Respiratory Modeling was called the Synchrony System prior to April 2020.
Synchrony Fiducial Tracking with Respiratory Modeling was called Fiducial Tracking with the Synchrony System
Synchrony Lung Tracking with Respiratory Modeling was call Xsight Lung with Synchrony System