Prostate SBRT with the CyberKnife® System

The premier solution for low and intermediate risk prostate cancer

The CyberKnife® System is designed to streamline and optimize Stereotactic Body Radiation Therapy (SBRT) to benefit your practice and your patients.

Patient in need of lung Stereotactic Body Radiation Therapy (SBRT) with the Accuray CyberKnife System after receiving

Precise robotic treatment as individual as every patient

The CyberKnife System combines advanced robotic treatment and sophisticated imaging algorithms to track and automatically correct for the prostate unpredictable motion and rotation, enabling the clinical team to deliver high doses of radiation with extreme precision and providing the patient with personalized treatment.

Demonstrated Clinical Benefits

Two large prospective, multi-institutional and CyberKnife® System only clinical studies report excellent clinical outcomes at five years post-treatment. These studies, conducted at academic and community medical centers across the United States, provide robust clinical data supporting the safety and efficacy of CyberKnife Stereotactic Body Radiotherapy (SBRT) for patients with low- and intermediate-risk prostate cancer.

Prospective evaluation of CyberKnife System stereotactic radiosurgery for low and intermediate risk prostate cancer:

Homogenous Dose Distribution

Prospective evaluation of CyberKnife System stereotactic radiosurgery for low and intermediate risk prostate cancer:

Emulating HDR brachytherapy dosimetry

Clinical Update

Dr. Nicholas van As presented acute toxicity results from the PACE trial at ASCO GU 2019. The study showed that there was no statistical difference between toxicity following conventionally fractionated RT or SBRT in men with early stage, organ-confined prostate cancer.

Proven Results

Listen to Dr. Robert Meier discuss the clinical results of a 5-year prospective study of prostate SBRT with the CyberKnife System.

Customer Testimonials

CyberKnife® Prostate Cancer Patient Experience
Watch Gerhard Hirsbrunner share his story from Inselspital Bern in Switzerland

CyberKnife® Treatment for Prostate Cancer
Listen to Dr. Donald B. Fuller who was an early adopter of the CyberKnife System

Unmatched Precision & Versatility

Accuray CyberKnife Prostate

Automatic 6D Correction

The CyberKnife’s image-guidance system continually acquires stereoscopic kV images during treatment, tracks motion and automatically corrects the treatment beam alignment in real-time1. The 6-axis robotic arm aims each beam of radiation taking into account any translational and rotational changes. All measured displacements are automatically corrected, regardless of how small, maintaining sub-millimeter accuracy1-7.

Frameless stereotactic targeting

The CyberKnife System enables stereotactic targeting without a stereotactic frame, enhancing patient comfort and simplifying the procedure. Simple immobilization devices such as thermoplastic masks, a foam cradle or vacuum bags keep the patient comfortably in treatment position and prevent large displacements that cannot be compensated by the robotic arm.

Illustration of frameless stereotactic targeting for prostate cancer with the CyberKnife System from Accuray
CyberKnife Prostate

Sharp dose gradient

The robotic design of the CyberKnife System seamlessly delivers non-coplanar, non-isocentric and isocentric beams. This wide range of available beam angles sculpts conformal dose distributions and enables safe and effective treatments regardless of the disease complexity and location. It generates the sharp dose gradient required for lesions close to critical structures and minimizes dose delivered to normal tissues.

Validated accuracy

The CyberKnife system uses proprietary anatomy-specific algorithms to track tumor motion. These specialized image guidance algorithms enable sub-millimeter precision and accuracy without the need for invasive and cumbersome stereotactic frame 1-7. Academic institutions have independently validated the image guidance sub-millimeter accuracy.

CyberKnife Prostate

6D Skull Tracking, total system error:

  • 0.95 mm (Accuray Specification)
  • 0.48 ± 0.22 mm2
  • 0.30 ± 0.12 mm6
  • 0.44 ± 0.12 mm3

Fiducial Tracking, total system error:

  • 0.95 mm (Accuray Specification)
  • 0.29 ± 0.10 mm3

Xsight® Spine Tracking, total system error:

  • 0.95 mm (Accuray Specification)
  • 0.53 ± 0.16 mm3
  • 0.52 ± 0.22 mm4
  • 0.61 ± 0.27 mm5

Synchrony® Respiratory Tracking System, total system error:

  • 0.95 mm (Accuray specification)
  • < 0.6 mm7

Versatility in collimator options

The CyberKnife System offers a collection of available collimators, providing the versatility needed to treat a wide range of clinical indications from trigeminal neuralgia to large tumors.

  • Fixed Circular Collimators
  • Iris Variable Aperture Collimator
  • InCise 2 Multileaf Collimator

Exceptional Patient Satisfaction12



would choose CyberKnife treatment again



report CyberKnife treatment did not interrupt their normal life routine



would recommend CyberKnife treatment to others

Clinical Examples

CyberKnife System Accuracy:

1. Kilby W. et al. “The CyberKnife® Robotic Radiosurgery System in 2010” TCRT. 2010; 9(5): 433-452 –

2. Muacevic A. et al. “Feasibility, safety, and outcome of frameless image-guided robotic radiosurgery for brain metastases.” J Neurooncol. 2010; 97: 267-274

3. Antypas C. and Pantelis E. “Performance evaluation of a CyberKnife G4
image-guided robotic stereotactic radiosurgery system.” Phys Med Biol.
53:4697-4718, 2008

4. Muacevic A. et. al. “Technical description, phantom accuracy, and clinical feasibility for fiducial-free frameless real-time image-guided spinal radiosurgery” J Neurosurgery Spine. 2006; 5(4): 303-312 –

5. Ho et. al. “A study of the accuracy of cyberknife spinal radiosurgery using skeletal structure tracking” Neurosurgery. 2007; 60: 147-156

6. Romanelli P. et al. “Image-Guided Robotic Radiosurgery for Trigeminal Neuralgia” Neurosurgery. 2017; Nyx571 –

7. Muacevic A. et. al. “Technical Description, Phantom Accuracy, and Clinical Feasibility for Single-session Lung Radiosurgery Using Robotic Image-guided Real-time Respiratory Tumor Tracking” TCRT. 2007; 6(4): 321-328 –

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The CyberKnife is the only prostate SBRT device supported by extensive published clinical follow-up. Nearly 100 peer-reviewed scientific articles support CyberKnife prostate SBRT safety and efficacy.

  • The CyberKnife System has been used to treat prostate cancer for 15 years and more than 20,000 prostate patients to date.
  • DFS rates for low-risk patients are superior to the 92-94% observed in external beam radiotherapy historic data.
  • DFS rates for low-risk patients are equivalent to low-dose-rate (LDR) brachytherapy and high-dose-rate (HDR) brachytherapy—without the inconvenience and risk associated with invasive seed and catheter implants.
  • DFS rates for intermediate-risk patients are equal to or higher than the 85-90% reported with external beam radiotherapy.


The only device that delivers continual image guidance and automatic 6D motion correction.


Significantly reduces patient inconvenience and treatment cost, requiring just 4-5 visits instead of 30-40 with external beam radiotherapy.


Continuous motion tracking and correction provides unparalleled preservation of healthy tissue—minimizing side effects on urinary, bowel, and sexual function.


Unmatched precision enables aggressive SBRT treatments that provide excellent long-term disease control for prostate patients.

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